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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제14권 제1호
- 발행연도
- 2016.1
- 수록면
- 109 - 113 (5page)
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초록· 키워드
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Brain-derived neurotrophic factor (BDNF) is linked to numerous brain functions. In addition, BDNF alterations contribute to neurological, mental, and addictive disorders. Cocaine dependence has received much attention recently due to its prevalence and psychological effects. Symptoms of psychosis are one of the most serious adverse events precipitated by cocaine use. It is particularly important to identify patients at risk of developing cocaine-induced psychosis (CIP). We described two cases of patients with cocaine dependence who presented with CIP and had changes in their BDNF levels during the psychotic episode.
BDNF levels were initially low in both patients, and then decreased by more than 50% in association with CIP. The relationship between BDNF and psychosis is described in the literature. These cases revealed that BDNF levels decreased during a CIP episode and, thus, it is necessary to investigate BDNF and its relationship with CIP further.
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참고문헌 (25)
참고문헌 신청
Milawaty Nurjono / 2012 / A Review of Brain-derived Neurotrophic Factor as a Candidate Biomarker in Schizophrenia / Clinical Psychopharmacology and Neuroscience 10(2):61~70
Nieto R / 2013 / BDNF and schizophrenia:from neurodevelopment to neuronal plasticity, learning, and memory / Front Psychiatry 4:45
Corominas-Roso M / 2013 / Brain-derived neurotrophic factor serum levels in cocaine-dependent patients during early abstinence / Eur Neuropsychopharmacol 23:1078~1084
Corominas M / 2007 / Brain-derived neurotrophic factor and its intracellular signaling pathways in cocaine addiction / Neuropsychobiology 55:2~13
Corominas-Roso M / 2013 / Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms / Neuropsychobiology 68:146~155
Nieto R / 2013 / BDNF and schizophrenia:from neurodevelopment to neuronal plasticity, learning, and memory / Front Psychiatry 4:45
Corominas-Roso M / 2013 / Brain-derived neurotrophic factor serum levels in cocaine-dependent patients during early abstinence / Eur Neuropsychopharmacol 23:1078~1084
Corominas M / 2007 / Brain-derived neurotrophic factor and its intracellular signaling pathways in cocaine addiction / Neuropsychobiology 55:2~13
Corominas-Roso M / 2013 / Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms / Neuropsychobiology 68:146~155
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