지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.6
- 수록면
- 119 - 128 (10page)
이용수
초록· 키워드
오류제보하기
Retinal pigment epithelium (RPE) constituting the outer blood-retina barrier plays an important role in ocular defense mechanism. Many studies reported that RPE participates in ongoing immune responses in the retina. However, the exact mechanism is still uncertain. Toll-like receptors (TLRs) participate in the recognition of pathogen-associated molecular patterns (PAMP), such as LPS, zymosan, lipoprotein, and dsRNA. The expression and function of TLRs in human RPE have not been established. In this study, we investigated TLRs expression in human fetal RPE and their recognition of PAMP to determine how human RPE participates in ocular defense mechanism against microbial component. RT-PCR and real time PCR revealed that TLR1 through 5 were constitutively expressed in human fetal RPE, and their expressions were slightly increased by LPS. We determined the TNF-α, IL-6, and IL-8 expression in human fetal RPE after treatment with LPS, zymosan, petidoglycan, or poly I:C. RT-PCR demonstrated that LPS and poly I:C treatment increased the production of TNF-α, IL-6, and IL-8 in human fetal RPE. LPS showed more potent effects on TNF-α and IL-8 production. Peptidoglycan and zymosan did not induce the production of TNF-α. CD14, the co-receptor of LPS was weakly expressed and functioned in recognizing LPS in human fetal RPE. These results suggest that human RPE may participate in ocular defense mechanism against microbial component through toll-like receptors.
목차
서론
재료 및 방법
결과
고찰
참고문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
사람 망막색소상피에서 Poly I:C가 Toll-like Receptor3와 사이토카인 발현에 미치는 영향
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2007 .12
-
LPS Sensing Mechanism of Human Astrocytes : Evidence of Functional TLR4 Expression and Requirement of Soluble CD14
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2017 .12
-
Individual LPS Responsiveness Depends on the Variation of Toll-like Receptor(TLR) Expression Level
Journal of Microbiology and Biotechnology
2007 .01
-
Recognition of lipopolysaccharide pattern by TLR4complexes
Experimental and Molecular Medicine
2013 .01
-
Ligand Recognition by the Toll-like Receptor Family
Animal cells and systems
2009 .01
-
Toll-like receptor signal transduction
Experimental and Molecular Medicine
2007 .01
-
Toll-like Receptors and Innate Immunity
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2011 .12
-
Gender Comparison of Ratings of Perceived Exertion (RPE) as a Predictor of Exercise Intensity in College Students
생명과학회지
2011 .01
-
Cooperative Interactions between Toll-Like Receptor 2 and Toll-Like Receptor 4 in Murine Klebsiella pneumoniae Infections
Journal of Microbiology and Biotechnology
2017 .01
-
Fiber Type Specific Expression of Toll-like Receptor4, IL-6, TNF-α, and Suppressor of Cytokine Signaling-3 after Acute Exercise in Rat Skeletal Muscles
생명과학회지
2011 .09
-
Systems Biological Approaches Reveal Non-additive Responses and Multiple Crosstalk Mechanisms between TLR and GPCR Signaling
Genomics & informatics
2012 .01
-
Toll-like Receptor 4-mediated Apoptotic Cell Death in Primary Isolated Human Cervical Cancers
생명과학회지
2018 .06
-
Carnosic acid inhibits TLR4-MyD88 signaling pathway in LPS-stimulated 3T3-L1 adipocytes
Nutrition Research and Practice
2014 .10
-
Carnosic acid inhibits TLR4-MyD88 signaling pathway in LPS-stimulated 3T3-L1 adipocytes
Nutrition Research and Practice
2014 .10
-
Structural analysis of human Toll-like receptor 3.
한국결정학회 학술연구발표회
2007 .01
-
결핵균 튜베르쿨린 PPD 및 38-kDa 항원에 의한 사람 말초혈액 단핵구의 전염증성 사이토카인 생성에 대한 Toll-like Receptor 의존도 비교 분석
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2007 .03
-
Negative regulatory approaches to the attenuation of Toll-like receptor signaling
Experimental and Molecular Medicine
2013 .01
-
A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice
Experimental and Molecular Medicine
2019 .01
-
Toll-Like Receptors as Pattern Recognition Receptors of Microbial Lipids
한국미생물학회 학술대회논문집
2008 .05
-
Nucleic Acid Recognition and Signaling by Toll-like Receptor 9
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2011 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2010-475-002457841