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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.2
- 수록면
- 35 - 41 (7page)
이용수
초록· 키워드
오류제보하기
It should be concerned to the women with mutated genotype of methylenetetrahydrofolate reductase (MTHFR), C677T or A1298C, since they need more folate than those with wild genotypes. In this study, we evaluated the folate status of Korean women of childbearing age according to their MTHFR polymorpiysm. Dietary folate intakes, plasma and erythrocyte folate concentrations, plasma homocysteine concentrations, and urinary excretions of para-aminobenzoylglutamate (pABG) and para-acetoamidobenzoylglutamate (ApABG) of twenty-five subjects aged between 19 and 35 years old were determined Folate intakes seemed to be inadequate, being only three-quarters of the Korean RDA of folate. More than one-quarter of the subjects was exposed to folate deficiency risk as determined by erythrocyte folate concentration and almost one-quarter of the subjects showed hyperhomocysteinemia, although they had normal plasma folate concentrations. Urinary excretions of pABG and ApABG seemed to be low and ApABG constituted more than 85% of total folate catabolites. 'There were no significant differences in dietary folate intakes, plasma concentrations of folate and homocysteine, and urinary excretions of PABG and ApABG among the geneotypes of both C677T and A1298C. However, the subjects with 1298AC genotype had significantly lower erythrocyte folate concentration than those with 1298AA. Erythrocyte folate concentration showed an inverse relationship with plasma homocysteine concentration and positive relationships with urinary excretions of pAnG and ApABG. 'The results of this study imply that mutations of 677C→T and 1298A→C in the study were not associated with decreased plasma folate and raised plasma homocysteine concentrations. A1298C polymorphism night be, however, more influential on erythrocyte folate concentration than C677T polymorphism, and urinary excretions of folate catabolites, pABG and ApABG, might be reliable indexes of folate nutritional status like plasma homocysteine concentrations.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSIONS
SUMMURY AND CONCLUSION
Literature Cited
참고문헌 (37)
참고문헌 신청
[학술지(정기간행물)] - / 1993 / Folates and fetal development : 307 ~ 309
[학술지(정기간행물)] - / 2000 / Dietary intakes and status of folate in Korean women of child bearing potential 33 (3) : 296 ~ 303
[학술지(정기간행물)] - / 1999 / Blood folate level determined by a microplate reader and folate intake measured by a weighted food record 4 (4) : 512 ~ 520
[학술지(정기간행물)] - / 2002 / The Significance of Homocysteine in Epileptic Patients 6 (1) : 20 ~ 26
[학술지(정기간행물)] - / 1999 / Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial 129 (6) : 1135 ~ 1139
[학술지(정기간행물)] - / 2000 / Dietary intakes and status of folate in Korean women of child bearing potential 33 (3) : 296 ~ 303
[학술지(정기간행물)] - / 1999 / Blood folate level determined by a microplate reader and folate intake measured by a weighted food record 4 (4) : 512 ~ 520
[학술지(정기간행물)] - / 2002 / The Significance of Homocysteine in Epileptic Patients 6 (1) : 20 ~ 26
[학술지(정기간행물)] - / 1999 / Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial 129 (6) : 1135 ~ 1139
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UCI(KEPA) : I410-ECN-0101-2012-594-004194710