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논문 기본 정보

자료유형
학술저널
저자정보
Gillian Lindzon (University of Toronto) Deborah L. O’Connor (University Avenue)
저널정보
한국영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.1 No.3
발행연도
2007.9
수록면
163 - 174 (12page)

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Folate has received international attention regarding its role in the risk-reduction of birth defects, specifically neural tube defects (NTDs). In 1998, health officials in Canada, like the United States, mandated the addition of folic acid to white flour and select grain products to increase the folate intake of reproductive-aged women. Subsequent to this initiative there has been an increase in blood folate concentrations in Canada and a 50 % reduction in NTDs. Many countries, including Korea, have not mandated folic acid fortification of their food supply. Reasons vary but often include concern over the masking of vitamin B12 deficiency, a belief that folate intakes among womenare adequate, low priority relative to other domestic issues, and the philosophy that individuals have the right not to consume supplemental folic acid if they so choose. Prior to folic acid fortification of the food supply in Canada, the folate intakes of women were low, and their blood folate concentrations while not sufficiently low to produce overt signs of folate deficiency (eg. anemia) were inconsistent with a level known to reduce the risk of an NTD-affected pregnancy. The purpose of this article is to describe the role of folate during the periconceptional period, pregnancy, and during lactation. The rationale for, and history of recommending folic acid-containing supplements during the periconceptional period and pregnancy is described as is folic acid fortification of the food supply. The impact of folic acid fortification in Canada is discussed, and unresolved issues associated with this policy described. While the incidence of NTDs in Canada pre-folic acid fortification were seemingly higherthan that of Korea today, blood folate levels of Korean women are strikingly similar. We will briefly explore these parallels in an attempt to understand whether folic acid fortification of the food supply in Korea might be worth consideration
#Folic acid #fortification #periconceptional period #pregnancy #lactation

목차

Abstract
Introduction
Function
Recommended Dietary Intake?
Folate During The Periconceptional Period
Folate During Pregnancy (Post-Closure of The Neural Tube)
Folate During Lactation-Impact On The Nursing Infant
Women at Increased Risk of Sub-Optimal Folate Nutrition
What is the History of Folic Acid Fortification in Canada?
What Has Been the Impact of Folic Acid Fortification on Folate Status of Women and the Prevalence of NTDs?
Necessity of Using Folic Acid-Containing Supplements Post Folic Acid Fortification of the Food Supply in Canada
Dietary Sources Consumed by Women in Canada and Korea
Blood Folate Concentrations of Korean Women: are They Consistent with Prevention of Neural Tube Defects
Rates of NTDs in Korea
Recommendations and Conclusions
Literature Cited

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