지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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To investigate the effect of dietary phosphatidylcholine(PPC) supplement on memory improvement，biochemical study on the brain, and morphometric studies on the cholinergic neurons in the rat basal forebrain were undertaken. The pregnancy rats were divided into the normal control， the cho1ine deficient and the PPC supplemental groups according to quantity of the PPC in diet.
According to choline deficiency and PPC supplement after birth， the neonate rats of the normal control group were subdivided into the control diet(N-N) and the PPC supplied(N-S) groups, the choline deficient group were subdivided into the continually deficient (D-D), the control diet(D-N) and the PPC supplied groups(D-S), and the PPC supplemental group were subdivided into the control dict(S-N) and the continually supplied(S-S) groups. The PPC supplemented diet was added 2% egg PPC in AIN 76 formula diet. PPC concentrations and choljnesterase(CE) activities were measured in the serum, the liver and the brain, respectively.
Immunohistochemical stains for choline acetyltransferase(ChAT) was employed for the morphological and morphometric studies.
The maze test was undertaken to evaluate memory improvement. PPC concentration and CE activities in the serum， liver and the brain were high in the PPC supplemental groups and low in the choline deficient groups. ChAT immunoreactivity neurons at the medical septal diagonal band complex and the basal forebrain nucleus of Meynert reduced in the choline deficient groups.
Average failure rate for the maze test was lowest in the S-S group and the highest in the D-D group. Insufficient choline supply during the neuronal development would result in cholinergic neuronal damage, which could be prevented by adequate PPC supplement. It is consequently suggested that PPC supplement may be effective on memory improvement by maintaining the cholinergic neuronal activity in the basal forebrain of the rats. (Korean J Nutrition.32(8) : 864-869, 1999)
According to choline deficiency and PPC supplement after birth， the neonate rats of the normal control group were subdivided into the control diet(N-N) and the PPC supplied(N-S) groups, the choline deficient group were subdivided into the continually deficient (D-D), the control diet(D-N) and the PPC supplied groups(D-S), and the PPC supplemental group were subdivided into the control dict(S-N) and the continually supplied(S-S) groups. The PPC supplemented diet was added 2% egg PPC in AIN 76 formula diet. PPC concentrations and choljnesterase(CE) activities were measured in the serum, the liver and the brain, respectively.
Immunohistochemical stains for choline acetyltransferase(ChAT) was employed for the morphological and morphometric studies.
The maze test was undertaken to evaluate memory improvement. PPC concentration and CE activities in the serum， liver and the brain were high in the PPC supplemental groups and low in the choline deficient groups. ChAT immunoreactivity neurons at the medical septal diagonal band complex and the basal forebrain nucleus of Meynert reduced in the choline deficient groups.
Average failure rate for the maze test was lowest in the S-S group and the highest in the D-D group. Insufficient choline supply during the neuronal development would result in cholinergic neuronal damage, which could be prevented by adequate PPC supplement. It is consequently suggested that PPC supplement may be effective on memory improvement by maintaining the cholinergic neuronal activity in the basal forebrain of the rats. (Korean J Nutrition.32(8) : 864-869, 1999)
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UCI(KEPA) : I410-ECN-0101-2012-594-004459285