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논문 기본 정보

자료유형
학술저널
저자정보
Sang K. Noh (창원대학교) Juyeon Kim (창원대학교)
저널정보
한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.16 No.2
발행연도
2011.6
수록면
104 - 109 (6page)

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초록· 키워드

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Recently, we have demonstrated that green tea extract (GTE) decreases the intestinal absorption of benzo[a]pyrene (BAP), which is an extremely lipophilic food contaminant. The present study was conducted to examine if an enteral infusion of GTE would influence the biliary secretion of BAP and lipids in rats. Female rats were fed an AIN-93G diet with or without (control) GTE at 5 g/㎏ diet for 4 week. Following the 4-week dietary treatment, rats with bile duct cannula were infused continuously for 8 hr at 3.0 ㎖/hr via a duodenal catheter with a lipid emulsion containing 4.0 μ㏖ BAP labeled with ¹⁴C (¹⁴C-BAP), 20.7 μmol cholesterol, 452 μ㏖ triolein, and 3.1 μ㏖ α-tocopherol, and 396.0 μ㏖ Na-taurocholate with or without 76.1 ㎎ GTE powder in PBS buffer (pH, 6.4). Bile was collected hourly via bile cannula for an 8 hr period. Our results showed that bile flow did not differ between groups. However, the biliary secretion of ¹⁴C-BAP was significantly enhanced by GTE infusion, compared with those infused with the lipid emulsion alone. However, GTE did not affect the biliary outputs of cholesterol, fat, phospholipid and α-tocopherol. These findings indicate that GTE has a profound stimulatory effect on the biliary excretion of BAP in rats, without affecting other biliary lipids. The mechanism(s) by which GTE enhances the biliary secretion of BAP remains to be investigated.

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Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENT
REFERENCES

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