지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 1,509 - 1,520 (12page)
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Purpose : The purpose of this study is to investigate endurance exercise and amino acid supplement induced changes in the expression of Akt, mTOR, myoD, and myogenin in the atrophied rat skeletal muscle by hindlimb suspension.
Method : Male Sprague-Dawley rats(n=42) were randomly placed in one of four groups(control, supplement, exercise, supplement&exercise) after 10days atrophy by hindlimb suspension. The Rat in the exercised groups ran the treadmill running for the intensity 30~60min 8~24M/min with degree slope 0°. The Rat in the supplemented groups had oral supplementation of 1ml of Amino acid twice per day(am/pm). The western blotting analysis performed for the expression of Akt, mTOR, myoD, myogenin protein.
Results : The expression of Akt significantly increased in one week and gradually decreased in following second and fourth weeks. The expression of mTOR significantly increased in the second week than the first week but decreased in the fourth week. The expression of myoD significantly increased gradually by time passing. The expression of myogenin increased in one week and gradually decreased in following weeks and increased insignificantly in supplemented group.
Conclusion : This study can be concluded that combinational treatment with endurance exercise and amino acid supplement has positive effects on recovery of atrophied skeletal muscle by controlling expression of Akt, mTOR, myoD and myogenin involved in protein synthesis and muscle regeneration.
Method : Male Sprague-Dawley rats(n=42) were randomly placed in one of four groups(control, supplement, exercise, supplement&exercise) after 10days atrophy by hindlimb suspension. The Rat in the exercised groups ran the treadmill running for the intensity 30~60min 8~24M/min with degree slope 0°. The Rat in the supplemented groups had oral supplementation of 1ml of Amino acid twice per day(am/pm). The western blotting analysis performed for the expression of Akt, mTOR, myoD, myogenin protein.
Results : The expression of Akt significantly increased in one week and gradually decreased in following second and fourth weeks. The expression of mTOR significantly increased in the second week than the first week but decreased in the fourth week. The expression of myoD significantly increased gradually by time passing. The expression of myogenin increased in one week and gradually decreased in following weeks and increased insignificantly in supplemented group.
Conclusion : This study can be concluded that combinational treatment with endurance exercise and amino acid supplement has positive effects on recovery of atrophied skeletal muscle by controlling expression of Akt, mTOR, myoD and myogenin involved in protein synthesis and muscle regeneration.
목차
Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과 및 논의
Ⅳ. 결론 및 제언
참고문헌
참고문헌 (36)
참고문헌 신청
1. [학술지(정기간행물)] - Allen DL / 2001 / Different pathways regulate expression of the skeletal myosin heavy chain genes / J Biol Chem 276 (47) : 43524 ~ 43533
2. [학술지(정기간행물)] - Aragno M / 2004 / Oxidative stress impairs skeletal muscle repair in diabetic rats / Diabetes 53 (4) : 1082 ~ 1088
3. [학술지(정기간행물)] - Beugnet A / 2003 / Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability / Biochem J 372 (Pt 2) : 555 ~ 566
4. [학술지(정기간행물)] - Bolster DR / 2004 / Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling / Proc Nutr Soc 63 (2) : 351 ~ 356
5. [학술지(정기간행물)] - Deldicque L / 2005 / Increased IGF mRNA in human skeletal muscle after creatine supplementation / Med Sci Sports Exerc 37 (5) : 731 ~ 736
2. [학술지(정기간행물)] - Aragno M / 2004 / Oxidative stress impairs skeletal muscle repair in diabetic rats / Diabetes 53 (4) : 1082 ~ 1088
3. [학술지(정기간행물)] - Beugnet A / 2003 / Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability / Biochem J 372 (Pt 2) : 555 ~ 566
4. [학술지(정기간행물)] - Bolster DR / 2004 / Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling / Proc Nutr Soc 63 (2) : 351 ~ 356
5. [학술지(정기간행물)] - Deldicque L / 2005 / Increased IGF mRNA in human skeletal muscle after creatine supplementation / Med Sci Sports Exerc 37 (5) : 731 ~ 736
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UCI(KEPA) : I410-ECN-0101-2013-692-000489646