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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 325 - 330 (6page)
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Red ginseng saponin fraction-A (RGSF-A) contains a high percentage of panaxadiol saponins that were isolated from Korean red ginseng by ultrafiltration. The aim of this study was to elucidate the effects of RGSF-A on the porcine distal left anterior descending (LAD) coronary artery. The relaxant responses to RGSF-A were examined during contractions induced by 100 nM U46619 (9,11-dideoxy-9a,11a-methanoepoxy-prostaglandin F2a), a stable analogue of thromboxane A2. RGSF-A dose-dependently induced biphasic (fast- and slow-) relaxation in the distal LAD coronary artery in the presence of an intact endothelium. The fast-relaxation was quickly achieved in a minute, and then the slow-relaxation was slowly developed and sustained for more than thirty minutes after the administration of RGSF-A. The slow-relaxation had a tendency to be bigger than the fast-relaxation. Fast relaxation induced by RGSF-A was almost blocked by N<sub>ω</sub>-Nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase synthase inhibitor and 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), a guanylate cyclase inhibitor. However slow relaxation induced by RGSF-A was only partially inhibited by L-NAME and ODQ. In the endothelium-removed ring, RGSF-A evoked only slow-relaxation to a certain extent. These data suggest that RGSF-A induced both endothelium dependent fast- and slow-relaxation and endothelium independent slow-relaxation in the porcine distal LAD coronary artery. The endothelium dependent fast-relaxation is mediated by the nitric oxide (NO)-cGMP pathway, and the endothelium dependent slow-relaxation is at least partially mediated by the NO-cGMP pathway. However, the endothelium-independent slow-relaxation remains to be elucidated.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (25)
참고문헌 신청
1. [학술지(정기간행물)] - Attele AS / 1999 / Ginseng pharmacology: multiple constituents and multiple actions / Biochem Pharmacol 58 : 1685 ~ 1693
2. [학술지(정기간행물)] - Furukawa T / 2006 / Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones / Mol Pharm 70 : 1916 ~ 1924
3. [학술지(정기간행물)] - Jin-Gyeong Cho / 2010 / Physicochemical Characterization and NMR Assignments of Ginsenosides Rb1, Rb2, Rc, and Rd Isolated from Panax ginseng / Journal of Ginseng Research 34 (2) : 113 ~ 121
4. [학술지(정기간행물)] - Kaku T / 1975 / Chemico-pharmacological studies on saponins of Panax ginseng C. A. Meyer. II / Pharmacological part. Arzneimittelforschung 25 : 539 ~ 547
5. [학술지(정기간행물)] - 이석근 / 199912 / Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng / PHYTOTHERAPY RESEARCH 13 (8) : 641 ~ 644
2. [학술지(정기간행물)] - Furukawa T / 2006 / Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones / Mol Pharm 70 : 1916 ~ 1924
3. [학술지(정기간행물)] - Jin-Gyeong Cho / 2010 / Physicochemical Characterization and NMR Assignments of Ginsenosides Rb1, Rb2, Rc, and Rd Isolated from Panax ginseng / Journal of Ginseng Research 34 (2) : 113 ~ 121
4. [학술지(정기간행물)] - Kaku T / 1975 / Chemico-pharmacological studies on saponins of Panax ginseng C. A. Meyer. II / Pharmacological part. Arzneimittelforschung 25 : 539 ~ 547
5. [학술지(정기간행물)] - 이석근 / 199912 / Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng / PHYTOTHERAPY RESEARCH 13 (8) : 641 ~ 644
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