항비만 소재 개발을 위해 알쏭이모자반 추출물이 고지방식이로 비만이 유도된 흰쥐의 증체량 감소 및 지질저하 효과에 미치는 영향을 살펴보았다. 정상식이군(n=10)을 제외한 20마리의 Spraque-Dawley 계통의 수컷 흰쥐에게 총 칼로리의 42.5%가 지방인 고지방식이를 5주간 급여시킴으로써 비만을 유도하였다. 비만해진 흰쥐는 고지방식이군(HFD)과 알쏭이모자반 3%를 첨가한 고지방식이군(HFDSC)으로 군당 10마리씩 나누어서 실험하였다. 항비만 소재 개발을 위해 알쏭이모자반 추출물이 고지방식이로 비만이 유도된 흰쥐의 증체량 감소 및 지질저하 효과에 미치는 영향을 살펴보았다. 정상식이군(n=10)을 제외한 20마리의 Spraque-Dawley 계통의 수컷 흰쥐에게 총 칼로리의 42.5%가 지방인 고지방식이를 5주간 급여시킴으로써 비만을 유도하였다. 비만해진 흰쥐는 고지방식이군(HFD)과 알쏭이모자반 3%를 첨가한 고지방식이군(HFDSC)으로 군당 10마리씩 나누어서 실험하였다
Effect of Sargassum confusum extract on the reduction of body weight gain and lipid contents in obese rats were evaluated to find natural materials with anti-obesity benefits. After inducing obesity by feeding 42.5% high-fat diet for 5 weeks, each 10 Sprague-Dawley rats were randomly assigned to high-fat diet control (HFD) group and high-fat diet group containing 3% Sargassum confusum extract (HFDSC). Weight gain of HFD group (2.96±0.31 g/day) was significantly (p<0.05) higher as compared to that of normal diet (ND) group (2.19±0.17 g/day). Weights of adipose tissues of HFD group were higher than those of ND group. Body weight gain of HFDSC group, however, was 2.36±0.24 g/day, which was significantly (p<0.05) lower by 21% than that of HFD group. In addition, weights of epididymal and perirenal adipose tissues were lower by 15% and 16%, respectively, as compared to those of HFD group. Biochemical analyses showed that concentration of triglyceride, total cholesterol, and fatty acids were significantly (p<0.05) lower in HFDSC group. These results suggest that Sargassum confusum extract has a high potential as an anti-obesity material by reducing weight gain and obesity-related factors in serum.