지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.2
- 수록면
- 172 - 178 (7page)
이용수
초록· 키워드
오류제보하기
Fermented ginseng (FG) is an ethanol extract of ginseng radix processed with β-galactosidase. It was hypothesized that FG may exert anti-hyperlipidemic and anti-diabetic activities through modulating AMP-activated protein kinase (AMPK) in HepG2 human hepatoma cells. In this study, we showed that AMPK phosphorylation was stimulated by FG. These effects were abolished by pretreatment with an AMPK inhibitor, compound C. In addition, FG regulated the expression of genes associated with lipogenesis and lipolysis, thus causing suppression of hepatic triglyceride accumulation. In vivo study using db/db mice, FG reduced fasting plasma glucose, HbAlc, and insulin resistance index, when compared to diabetic control. FG also increased the phospho-AMPK and glucose transporter 4 (GLUT4) expressions in liver and skeletal muscle, respectively. In liver, expressions of lipogenic gene were decreased whereas expressions of lipolytic genes were induced, when compared to diabetic control. Taken together, we may suggest that FG ameliorates hyperglycemia and hyperlipidemia through activation of AMPK and could be developed as a health functional food or therapeutic agent for type 2 diabetic patients.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgment
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
3T3-L1 지방전구세포에서 1-O-feruloyl-β-D-glucose의 지방생성억제효과
Food Science and Preservation
2018 .10
-
Flavonoids activating adenosine monophosphate-activated protein kinase
Applied Biological Chemistry
2015 .01
-
Lactobacillus plantarum DR7 Reduces Cholesterol via Phosphorylation of AMPK That Down-regulated the mRNA Expression of HMG-CoA Reductase
한국축산식품학회지
2018 .01
-
Platycodi Radix Ameliorates Obesity-induced Insulin Resistance via Activation of AMPK Phosphorylation in the Muscle
한국식품영양과학회 학술대회발표집
2012 .10
-
근육세포 내 Glucose 농도와 AICAR에 의한 단백질 합성 저해
한국축산학회지
2012 .01
-
Seaweed Extracts Modulate the Glucose Uptake via an AMPK-dependent Pathway in C2C12 Skeletal Muscle Cells
한국식품영양과학회 학술대회발표집
2019 .10
-
Scopoletin Supplementation Modifies Expressions of CYP2E1 and AMPK in Ethanol-Induced Hepatic Injury in Mice
한국식품영양과학회 학술대회발표집
2011 .10
-
A Vinegar-processed Ginseng Radix (Ginsam) Ameliorates Hyperglycemia and Dyslipidemia in C57BL/KsJ db/db Mice
Food Science and Biotechnology
2008 .12
-
Perilla frutescens extract alleviates hyperglycemia and improves insulin resistance in db/db diabetic mice
한국식품영양과학회 학술대회발표집
2016 .10
-
Fermented New Herbal Formula (F-NPLPC) Extract Inhibits Lipid Accumulation and Blood Glucose via AMPK/GluT-4/PPAR gamma Activations in vitro and in vivo
한국식품영양과학회 학술대회발표집
2013 .11
-
Anti-diabetic Effect of Material Fermented Using Rice Bran and Soybean as the Main Ingredient by Bacillus sp.
Applied Biological Chemistry
2010 .01
-
Influence of pH, Emulsifier Concentration, and Homogenization Condition on the Production of Stable Oil-in-Water Emulsion Droplets Coated with Fish Gelatin
Food Science and Biotechnology
2007 .12
-
[P6-05] Effects of Fermented Red Ginseng Supplement on Blood Glucose and Insulin Resistance in Type II Diabetic Patients
한국식품영양과학회 학술대회발표집
2010 .10
-
Regulatation of Type 2 Diabetes Mellitus-Induced Non-Alcoholic Fatty Liver Disease through Activation of AMPK and PPAR-α by Black Ginseng
한국약용작물학회 학술대회논문집
2018 .05
-
Anti-diabetic effect of honokiol in type 2 diabetic db/db mice
한국식품영양과학회 학술대회발표집
2018 .10
-
AMPK 활성을 통한 Cryptotanshinone의 항암, 항비만 효과
한국식품영양과학회 학술대회발표집
2011 .10
-
The combination of Korean red ginseng and Glycyrrhiza glabra L. extracts enhances AMPK pathway activation in C57BL/6J obese mice
한국식품영양과학회 학술대회발표집
2019 .10
이 논문의 저자 정보
이 논문과 함께 이용한 논문
AMP-activated Kinase Regulates Adipocyte Differentiation Process in 3T3-L1 Adipocytes Treated with Selenium
Song Yi Pa
,
k
,
Jin-Taek Hwang
외 4명
생명과학회지
2009
.04
청미래덩굴 잎 물추출물이 처리된 HepG2 세포에서의 포도당흡수기전 연구
강윤환
,
김대중
,
김경곤
외 2명
Journal of Nutrition and Health
2014
.06
적소두가 비알코올성 지방간 질환 세포 모델에 미치는 효과
장영숙
,
서지윤
,
권민정
외 8명
동의생리병리학회지
2013
.12
인간 HepG2 세포에서 더덕 및 도라지 에틸아세테이트 분획물의 항산화 효과에 의한 세포보호 효과
김수현
,
최현진
,
오현택
외 3명
한국식품과학회지
2008
.12
지골피, 동충하초, 가시오가피 복합추출물이 고포도당 조건에서 배양한 HepG2 세포의 당대사 관련 효소 활성에 미치는 영향
김대중
,
김정미
,
김태혁
외 3명
한국식품영양과학회지
2010
.09
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-573-000856616