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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 1,285 - 1,288 (4page)
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The purpose of this study was to characterize and investigate the immune activity of CpG oligodeoxynucleotides (ODNs) from Bifidobacterium longum. Bacterial CpG motifs have attracted considerable interests because of their immunomodulatory activities. Genomic DNA from B. longum was prepared and amplified for 4 different 180-188-mer double-stranded ODNs (BLODN1-BLODN4). When immune cells (RAW 264.7 murine macrophages and JAWS II dendritic cells) with these ODNs were treated, BLODN4 induced the highest immune activity. To assess the effectiveness of the CpG sequences within BLODN4, single-stranded 40-mer ODNs containing CpG sequences (sBLODN4-1, sBLODN4-2) were synthesized. sBLODN4-1 induced higher level of cytokines such as interleukin (IL)-12p40 and tumor necrosis factor (TNF)-α by macrophage and IL-6 and TNF-α by dendritic cells than did sBLODN4-2. The results suggest that CpG ODNs-enriched components of B. longum might be useful as an immunomodulatory functional food ingredient.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (18)
참고문헌 신청
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Klijn A / 2005 / Lessons from the genomes of bifidobacteria / FEMS Microbiol. Rev 29:491~509
Sparwasser T / 1998 / Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells / Eur. J. Immunol 28:2045~2054
Stacey KJ / 1996 / Macrophages ingest and are activated by bacterial DNA / J. Immunol 157:2116~2122
Dunne C / 1999 / Probiotics: From myth to reality. Demonstration of functionality in animal models of disease and in human clinical trials / Anton. Leeuw. Int. J. G 76:279~292
Klijn A / 2005 / Lessons from the genomes of bifidobacteria / FEMS Microbiol. Rev 29:491~509
Sparwasser T / 1998 / Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells / Eur. J. Immunol 28:2045~2054
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UCI(KEPA) : I410-ECN-0101-2013-573-000858483