지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 1,294 - 1,298 (5page)
이용수
초록· 키워드
오류제보하기
Toll-like receptors (TLRs) induce innate immune responses recognizing conserved microbial structural molecules. All TLR signaling pathways culminate in the activation of nuclear factor-κB (NF-κB). The activation of NF-κB leads to the induction of inflammatory gene products such as cyclooxygenase-2 (COX-2). Guggul has been used for centuries to treat a variety of diseases. Guggulstreone, one of the active ingredients in guggul, has been used to treat many chronic diseases. However, the mechanism as to how guggulsterone mediate the health effects is largely unknown. Here, we report biochemical evidence that guggulsterone inhibits the NF-κB activation and COX-2 expression induced by TLR2, TLR3, and TLR4 agonists. Guggulsterone also inhibits the NF-κB activation induced by downstream signaling components of TLRs, myeloid differential factor 88 (MyD88), IκB kinase β (IKKβ), and p65. These results imply that guggulsterone can modulate the immune responses regulated by TLR signaling pathways.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (39)
참고문헌 신청
Takeda K / 2005 / Toll-like receptors in innate immunity / Int. Immunol 172:1~14
Medzhitov R / 2001 / Toll-like receptors and innate immunity / Nat. Rev. Immunol 1:135~145
O’Neill LA / 2004 / TLRs: Professor Mechnikov, sit on your hat / Trends Immunol 25:687~693
Vogel SN / 2003 / TLRs: Differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression / Mol. Interv 3:466~477
Poltorak A / 1998 / Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene / Science 282:2085~2088
Medzhitov R / 2001 / Toll-like receptors and innate immunity / Nat. Rev. Immunol 1:135~145
O’Neill LA / 2004 / TLRs: Professor Mechnikov, sit on your hat / Trends Immunol 25:687~693
Vogel SN / 2003 / TLRs: Differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression / Mol. Interv 3:466~477
Poltorak A / 1998 / Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene / Science 282:2085~2088
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
6-Shogaol의 Toll-like receptor 2, 3, 4 agonists에 의해서 유도된 cyclooxygenase-2 발현 억제
한국식품과학회지
2008 .06
-
Isoliquiritigenin의 toll-like receptor agonists에 의해서 유도된 NF-κB 활성화와 cyclooxygenase-2 발현 억제
한국식품과학회지
2009 .04
-
Toll-like receptor 2, 3, 4의 신호전달체계 조절을 통한 curcumin의 항암ㆍ항염증 효과
한국식품과학회지
2007 .04
-
Michael addition acceptor 그룹을 가지고 있는 phytochemicals의 toll-like receptor 신호전달체계 조절을 통한 항염증 효과
한국식품과학회지
2009 .10
-
Molecular Characterization of Chicken Toll-like Receptor 7
한국동물번식학회지
2015 .01
-
Toll-like receptors 신호전달체계 조절을 통한 resveratrol, (-)-epigallocatechin-3-gallate, curcumin의 항염증 효과
한국식품과학회지
2007 .10
-
Phenethyl Isothiocyanate가 Toll-like Receptor Agonists에 의해 유도된 Nuclear Factor-κB 활성과 Cyclooxygenase-2, Inducible Nitric Oxide Synthase 발현에 미치는 효과
Journal of applied biological chemistry
2011 .01
-
Expression patterns of innate immunity-related genes in response to polyinosinic:polycytidylic acid (poly[I:C]) stimulation in DF-1 chicken fibroblast cells
한국축산학회지
2020 .01
-
Procyanidin Trimer C1 Inhibits LPS-Induced MAPK and NF-κB Signaling through TLR4 in Macrophages
한국식품영양과학회 학술대회발표집
2012 .10
-
Anti-inflammatory effect of gamma-irradiated genistein through MAPK and NF-κB signaling based on TLR4 in LPS-induced macrophages
한국식품영양과학회 학술대회발표집
2013 .11
-
닭의 iNOS와 TLR-4 유전자 내 변이와 경제 형질 간의 연관성 분석
한국가금학회지
2013 .06
-
Caffeine inhibits LPS induced pro-inflammation through regulation of TLR4 signaling pathway in murine macrophage
한국식품영양과학회 학술대회발표집
2013 .11
-
[P10-163] Kaempferol Induces Apoptosis through Death ReceptorMediated Events : Mediation by the Activation of NF-κB Signaling
한국식품영양과학회 학술대회발표집
2006 .10
-
강황 추출물의 비알코올성 지방간 질환 개선 효과
한국약용작물학회지
2020 .08
-
Curcumin and 80% Ethanol Extract from Curcuma Longa L. attenuate Amyloid-β-induced Neuronal Damage and Indicated Possible Involvement of the TLR/NF-κ B Pathway
한국식품영양과학회 학술대회발표집
2016 .10
-
Loganin Attenuated β-Amyloid Peptide(25-35)-Induced Inflammation through the Regulation of NF-κB Signaling Pathway
한국식품영양과학회 학술대회발표집
2013 .11
-
TLR 4 Signaling Inhibitory Pathway Induced by Green Tea Polyphenol Epigallocatechin-3-Gallate through 67-kDa Laminin Receptor
한국식품영양과학회 학술대회발표집
2013 .11
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Toll-like receptors 신호전달체계 조절을 통한 resveratrol, (-)-epigallocatechin-3-gallate, curcumin의 항염증 효과
윤형선
한국식품과학회지
2007
.10
Toll-like receptor 2, 3, 4의 신호전달체계 조절을 통한 curcumin의 항암ㆍ항염증 효과
윤형선
,
강순아
,
Daniel Hwang
한국식품과학회지
2007
.04
Michael addition acceptor 그룹을 가지고 있는 phytochemicals의 toll-like receptor 신호전달체계 조절을 통한 항염증 효과
윤형선
한국식품과학회지
2009
.10
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-573-000858509