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논문 기본 정보

자료유형
학술저널
저자정보
Gun-Hee Kim (Duksung Women’s University) Yong-Ri Jin (Maine Medical Center Research Institute, 81 Research Drive Scarborough) Soon-Hyang You (Chungbuk National University) Hyeong-Jun Han (Chungbuk National University) Jung-Jin Lee (Chungbuk National University) Ji-Yeon Yu (Chungbuk National University) Ji-Hyun Im (Chungbuk National University) Eun-Suk Park (Chungbuk National University) Tack-Joong Kim (Yonsei University) Eunyoung Hong (Duksung Women’s University) Yeo-Pyo Yun (Chungbuk National University)
저널정보
한국식품과학회 Food Science and Biotechnology Food Science and Biotechnology vol 17. no 2
발행연도
2008.4
수록면
247 - 250 (4page)

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The CHCl<sub>3</sub>, EtOAc, and n-BuOH fractions showed a marked inhibition of 5% fatal bovine serum (FBS)-induced cell proliferation. The IC<sub>50</sub> values of the chloroform fractions from leaf, stem, and root as well as the n-BuOH and EtOAc fraction from root on cell proliferation were 1.2±0.4, 17.2±6.4, 81.8±33.2, 40.8±8.0, and 237.1±85.6 μg/mL, respectively. On the other hand, the EtOAc fractions, and the CHCl<sub>3</sub> fraction significantly inhibited collagen-, arachidonic acid-, U46619-, and thrombin-induced platelet aggregations. The IC<sub>50</sub> values of EtOAc fraction from leaf, and the CHCl<sub>3</sub> and EtOAc fraction from stem were 214.1±12.2, 134.3±2.5, and 42.6±7.0 μg/mL with collagen, 312.4±7.5, 158.9±1.7, and 82.2±2.7 μg/mL with arachidonic acid, 31.1±2.4, 48.7±0.3, and 29.7±1.1 μg/mL with U46619, and 36.7±2.4, 69.1±11.3, and 34.2±0.1 μg/mL with thrombin, respectively. Taken together, these data provide new evidence that fractions from Allium victorialis var. platyphyllum (AVP) are able to inhibit vascular smooth muscle cell (VSMC) proliferation and platelet aggregation, which may be a novel resource for the development of anti-atherothrombotic agents.

목차

Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References

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