지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 327 - 331 (5page)
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초록· 키워드
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Pancreatic β-cells are major cells responsible for glucose metabolism in the body. Hyperglycemia is known to be a primary factor in the induction of diabetes mellitus. Glutamate is also an excitatory neurotransmitter in diverse organs. Oxidative stress also plays a pivotal role in the development of diabetes mellitus. However, the effect of hyperglycemia in glutamate uptake in the pancreas is not clear. Furthermore, the relationship between high glucose-induced glutamate uptake and oxidative stress has not been investigated. Therefore, this study was conducted to investigate the effect of high glucose on glutamate uptake in pancreatic β-cells. In the present study, 25 mM glucose stimulated the glutamate uptake in HIT-15 cells of hamster pancreatic β-cells. The treatment of 25 mM glucose and 1 mM glutamate also decreased the cell viability in HIT-15 cells. In addition, the treatment of 25 mM glucose induced an increase of lipid peroxide formation. High glucose-induced increase of LPO formation was prevented by the treatment of antioxidants such as N-acetyl-L-cysteine and quercetin. Furthermore, high glucose-induced stimulation of glutamate uptake and decrease of cell viability were also blocked by the treatment of N-acetyl-L-cysteine and quercetin. In conclusion, high glucose stimulated glutamate uptake via oxidative stress in pancreatic β-cells.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Martens GA / 2009 / Glucose, regulator of survival and phenotype of pancreatic beta cells / Vitam Horm 80 : 507 ~ 539
2. [학술지(정기간행물)] - Thorens B / 2008 / Glucose sensing and the pathogenesis of obesity and type 2 diabetes / Int J Obes (Lond) 32 : 62 ~ 71
3. [학술지(정기간행물)] - Stumvoll M / 2007 / Pathogenesis of type 2 diabetes / Endocr Res 32 (1) : 19 ~ 37
4. [학술지(정기간행물)] - Spooren W / 2010 / Metabotropic glutamate receptors: their therapeutic potential in anxiety / Curr Top Behav Neurosci 2 : 391 ~ 413
5. [학술지(정기간행물)] - Yasuo T / 2008 / Multiple receptor systems for glutamate detection in the taste organ / Biol Pharm Bull 31 (10) : 1833 ~ 1837
2. [학술지(정기간행물)] - Thorens B / 2008 / Glucose sensing and the pathogenesis of obesity and type 2 diabetes / Int J Obes (Lond) 32 : 62 ~ 71
3. [학술지(정기간행물)] - Stumvoll M / 2007 / Pathogenesis of type 2 diabetes / Endocr Res 32 (1) : 19 ~ 37
4. [학술지(정기간행물)] - Spooren W / 2010 / Metabotropic glutamate receptors: their therapeutic potential in anxiety / Curr Top Behav Neurosci 2 : 391 ~ 413
5. [학술지(정기간행물)] - Yasuo T / 2008 / Multiple receptor systems for glutamate detection in the taste organ / Biol Pharm Bull 31 (10) : 1833 ~ 1837
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UCI(KEPA) : I410-ECN-0101-2013-510-001228151