Numerical Study on Effects of Liposome-Encapsulated Hemoglobin on Blood Flows at Microvascular Bifurcation with Considering Erythrocyte Aggregation

T. Hyakutake; Y. Akagi,; T. Imaru; T. Matsumto; S. Yanase

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자료유형: 학술대회자료

저자정보: T. Hyakutake (Yokohama National University) Y. Akagi, (Okayama University) T. Imaru (Okayama University) T. Matsumto (Osaka University) S. Yanase (Okayama University)

저널정보: 한국전산유체공학회 한국전산유체공학회 학술대회논문집 한국전산유체공학회 2010년도 추계학술대회

발행연도: 2010.11

수록면: 317 - 320 (4page)

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Flow analysis at microvascular bifurcation after partial replacement of red blood cell (RBC) with liposome-encapsulated hemoglobin (LEH) was performed. A two-dimensional bifurcation model with a parent vessel and two daughter branches was considered. Here, we adopted the lattice Boltzmann method(LBM) for the computation of blood flow. Moreover, the immersed boundary method was employed to incorporate the fluid-membrane interaction between the flow field and deformable RBCs. The cell membrane is treated as a neo-Hookean viscoelastic material. A Morse potential was adopted to model the intercorpuscular interaction. When the half of RBCs was replaced by isovolumic LEH particles, the biasing of RBC flow was enhanced. However, LEH particles flowed favorable into the lower-flow branch because many LEH particles within the parent vessel were suspended in the plasma layer that is impenetrable to RBCs. The biasing of the RBC flux was enhanced when the RBC aggregation was taken into account in the model. It was clarified that the RBC aggregation-induced change of the plasma layer thickness has a marked influence on the fractional LEH flux at the microvascular bifurcation.

#Liposome-Encapsulated Hemoglobin #Red Blood Cell #Microvascular Bifurcation Flow #Lattice Boltzmann method #Erythrocyte Aggregation

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