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Regulation of Skeletal Muscle Differentiation by Akt
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논문 기본 정보

Type
Academic journal
Author
Dae Han Woo (Pusan National University School of Medicine) Sung Ji Yun (Pusan National University School of Medicine) Eun Kyoung Kim (Pusan National University School of Medicine) Jung Min Ha (Pusan National University School of Medicine) Hwa Kyoung Shin (Pusan National University School of Korean Medicine)
Journal
Korean Society Of Life Science Journal of Life Science Vol.22 No.4 KCI Accredited Journals
Published
2012.4
Pages
447 - 455 (9page)

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Result
Regulation of Skeletal Muscle Differentiation by Akt
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Abstract· Keywords

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Akt plays an important role in a variety of cellular physiologies such as growth, proliferation, and differentiation. In skeletal muscle, Akt has been implicated in regulating regeneration, hypertrophy, and atrophy. In this study, the role of Akt has been examined during skeletal muscle differentiation. Culturing C2C12 myoblasts under low serum (1% horse serum) and high density converted cell morphology from a round shape to an elongated and multi-nucleated shape. Morphological changes were initiated from day 2 of differentiation. In addition, the expression of both myogenin G and myogenin D was elevated from day 2 of differentiation. Skeletal muscle differentiation was abolished by silencing Akt1 or Akt2, but was significantly enhanced by the over-expression of either Akt1 or Akt2. The activation of Akt was observed from day 2 of differentiation and disappeared after day 7. The expression of kruppel-like factor 4 was observed from day 6 of differentiation. Moreover, this expression was blocked in cells silencing either Akt1 or Akt2. In addition, the promoter activity of kruppel-like factor 4 was significantly reduced in cells silencing Akt1 or Akt2. These results suggest that Akt regulates skeletal muscle differentiation through the regulation of kruppel-like factor 4 expression.
#Muscle #differentiation #Akt #KLF4 #myogenin

Contents

Introduction
Materials and Methods
Results
Discussion
Acknowledgement
References
초록

References (38)

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1. [학술지(정기간행물)] - Alder, J. K. / 2008 / Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo / J. Immunol 180 : 5645 ~ 5652 google schola 2. [학술지(정기간행물)] - Banerjee, S. S. / 2003 / The Kruppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis / J. Biol. Chem 278 : 2581 ~ 2584 google schola 3. [학술지(정기간행물)] - Basu, P. / 2005 / KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic β-like globin genes in vivo / Blood 106 : 2566 ~ 2571 google schola 4. [학술지(정기간행물)] - Bodine, S. C. / 2001 / Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo / Nat. Cell Biol 3 : 1014 ~ 1019 google schola 5. [학술지(정기간행물)] - Chen, W. S. / 2001 / Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene / Genes Dev 15 : 2203 ~ 2208 google schola

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