지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.11
- 수록면
- 355 - 361 (7page)
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초록· 키워드
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Purpose: Peritoneal recurrence after curative resection of colorectal cancer has been considered to be a lethal condition and to be suitable for palliative chemotherapy. Recently, aggressive approaches such as cytoreductive surgery and perioperative intraperitoneal chemotherapy were introduced for peritoneal malignancies to improve survival. The aim of this study is to identify the risk factors of peritoneal recurrence after curative resection of colorectal cancer and to determine the indication of early postoperative intraperitoneal chemotherapy (EPIC).
Methods: From January 1997 to December 2007, a total of 2,320 patients’ records with curative resection for colorectal cancer were collected through the prospective colorectal cancer registry protocol in Kyungpook National University Hospital, Korea. Of those, a total of 1,929 patients were included for analysis of the relationship between perioperative clinicopathologic variables and peritoneal recurrence.
Results: The study group was composed of 1,086 men and 843 women with a mean age of 61.1. In multivariate analysis, preoperative level of serum CA19-9＞37 U/㎖ (odd ratio [OR] 3.217; 95% confidence interval [95% CI] 1.525∼6.788), right colon cancer (OR 2.524; 95% CI 1.158∼5.502), pT4 tumor (OR 2.131; 95% CI 1.009∼4.502) and positive apical lymph node (OR 3.045; 95% CI 1.023∼9.066) were independent risk factors of peritoneal recurrence after curative resection of colorectal cancer.
Conclusion: In colorectal cancer patients with increased preoperative serum levels of CA19-9, right-sided location, serosal exposure or invasion of adjacent organ, and positive apical lymph node, more scrupulous surveillance for peritoneal recurrence was necessary during the postoperative follow-up period. In selective patients with risk factors of peritoneal recurrence, more aggressive strategies for management, such as EPIC, were able to be considered under the acceptable general condition and life-expectancy.
Methods: From January 1997 to December 2007, a total of 2,320 patients’ records with curative resection for colorectal cancer were collected through the prospective colorectal cancer registry protocol in Kyungpook National University Hospital, Korea. Of those, a total of 1,929 patients were included for analysis of the relationship between perioperative clinicopathologic variables and peritoneal recurrence.
Results: The study group was composed of 1,086 men and 843 women with a mean age of 61.1. In multivariate analysis, preoperative level of serum CA19-9＞37 U/㎖ (odd ratio [OR] 3.217; 95% confidence interval [95% CI] 1.525∼6.788), right colon cancer (OR 2.524; 95% CI 1.158∼5.502), pT4 tumor (OR 2.131; 95% CI 1.009∼4.502) and positive apical lymph node (OR 3.045; 95% CI 1.023∼9.066) were independent risk factors of peritoneal recurrence after curative resection of colorectal cancer.
Conclusion: In colorectal cancer patients with increased preoperative serum levels of CA19-9, right-sided location, serosal exposure or invasion of adjacent organ, and positive apical lymph node, more scrupulous surveillance for peritoneal recurrence was necessary during the postoperative follow-up period. In selective patients with risk factors of peritoneal recurrence, more aggressive strategies for management, such as EPIC, were able to be considered under the acceptable general condition and life-expectancy.
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REFERENCES
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Brodsky JT / 1991 / Peritoneal seeding following potentially curative resection of colonic carcinoma: implications for adjuvant therapy / Dis Colon Rectum 34 : 723 ~ 727
2. [학술지(정기간행물)] - Koppe MJ / 2006 / Peritoneal carcinomatosis of colorectal origin: incidence and current treatment strategies / Ann Surg 243 : 212 ~ 222
3. [학술지(정기간행물)] - Chu DZ / 1989 / Peritoneal carcinomatosis in nongynecologic malignancy. A prospective study of prognostic factors / Cancer 63 : 364 ~ 367
4. [학술지(정기간행물)] - Sadeghi B / 2000 / Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study / Cancer 88 : 358 ~ 363
5. [학술지(정기간행물)] - Glehen O / 2004 / Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: a multi-institutional study / J Clin Oncol 22 : 3284 ~ 3292
2. [학술지(정기간행물)] - Koppe MJ / 2006 / Peritoneal carcinomatosis of colorectal origin: incidence and current treatment strategies / Ann Surg 243 : 212 ~ 222
3. [학술지(정기간행물)] - Chu DZ / 1989 / Peritoneal carcinomatosis in nongynecologic malignancy. A prospective study of prognostic factors / Cancer 63 : 364 ~ 367
4. [학술지(정기간행물)] - Sadeghi B / 2000 / Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study / Cancer 88 : 358 ~ 363
5. [학술지(정기간행물)] - Glehen O / 2004 / Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: a multi-institutional study / J Clin Oncol 22 : 3284 ~ 3292
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