지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.5
- 수록면
- 307 - 315 (9page)
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Purpose: We aimed to investigate the correlations between expressions of angiogenic cytokines VEGF-A, C, D of primary colorectal cancer and liver metastasis.
Methods: We examined paraffin-embedded primary colorectal cancer tissue from 45 patients who had liver resection due to colorectal liver metastasis (metastasis group) and 37 patients who had surgical resection due to colorectal cancer only (control group). In the control group, local recurrence and distant metastasis had not occurred. Immunohistochemical staining for VEGF-A, C and D was performed. We analysed the correlations between expression of VEGF-A, C and D in primary colorectal cancer tissues and clinicopathologic parameters.
Results: VEGF-A expressions of primary colorectal carcinoma were not different between the two groups. VEGF-C was more frequently expressed in the metastasis group (P=0.008) but VEGF-D was more expressed in the control group (P=0.003). Patients with VEGF-C negative and VEGF-D positive expression were predominant in the control group (P=0.020). Tumor location, T stage, lymph node metastasis and tumor differentiation were not related with the expressions of VEGF-A, C, D but only preoperative CEA was positively correlated with VEGF-A and C expression.
Conclusion: Expressions of VEGF-C in primary tumor were more frequent in metastatic colorectal cancer and expressions of VEGF-D were more frequent in nonmetastatic colorectal cancer. More large-scale prospective studies for VEGF-C and D expression in colorectal cancer are necessary.
Methods: We examined paraffin-embedded primary colorectal cancer tissue from 45 patients who had liver resection due to colorectal liver metastasis (metastasis group) and 37 patients who had surgical resection due to colorectal cancer only (control group). In the control group, local recurrence and distant metastasis had not occurred. Immunohistochemical staining for VEGF-A, C and D was performed. We analysed the correlations between expression of VEGF-A, C and D in primary colorectal cancer tissues and clinicopathologic parameters.
Results: VEGF-A expressions of primary colorectal carcinoma were not different between the two groups. VEGF-C was more frequently expressed in the metastasis group (P=0.008) but VEGF-D was more expressed in the control group (P=0.003). Patients with VEGF-C negative and VEGF-D positive expression were predominant in the control group (P=0.020). Tumor location, T stage, lymph node metastasis and tumor differentiation were not related with the expressions of VEGF-A, C, D but only preoperative CEA was positively correlated with VEGF-A and C expression.
Conclusion: Expressions of VEGF-C in primary tumor were more frequent in metastatic colorectal cancer and expressions of VEGF-D were more frequent in nonmetastatic colorectal cancer. More large-scale prospective studies for VEGF-C and D expression in colorectal cancer are necessary.
목차
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방법
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결론
REFERENCES
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Park JK / 2001 / Prognostic factors affecting survival rate following hepatic resection for metastatic colorectal cancer / J Korean Surg Soc 61 : 583 ~ 587
2. [학술지(정기간행물)] - Jenkins LT / 1997 / Hepatic resection for metastatic colorectal cancer / Am Surg 63 : 605 ~ 610
3. [학술지(정기간행물)] - Yang Y / 2001 / P53 mutations in primary tumors and subsequent liver metastases are related to survival in patients with colorectal carcinoma who undergo liver resection / Cancer 91 : 727 ~ 736
4. [학술지(정기간행물)] - De Jong KP / 1998 / Clinical relevance of transforming growth factor alpha, epidermal growth factor receptor, p53, and Ki67 in colorectal liver metastases and corresponding primary tumors / Hepatology 28 : 971 ~ 979
5. [학술지(정기간행물)] - Folkman J / 1990 / What is the evidence that tumors are angiogenesis dependent? / J Natl Cancer Inst 82 : 4 ~ 6
2. [학술지(정기간행물)] - Jenkins LT / 1997 / Hepatic resection for metastatic colorectal cancer / Am Surg 63 : 605 ~ 610
3. [학술지(정기간행물)] - Yang Y / 2001 / P53 mutations in primary tumors and subsequent liver metastases are related to survival in patients with colorectal carcinoma who undergo liver resection / Cancer 91 : 727 ~ 736
4. [학술지(정기간행물)] - De Jong KP / 1998 / Clinical relevance of transforming growth factor alpha, epidermal growth factor receptor, p53, and Ki67 in colorectal liver metastases and corresponding primary tumors / Hepatology 28 : 971 ~ 979
5. [학술지(정기간행물)] - Folkman J / 1990 / What is the evidence that tumors are angiogenesis dependent? / J Natl Cancer Inst 82 : 4 ~ 6
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