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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 48 - 53 (6page)
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Purpose: Vascular endothelial growth factor (VEGF)-C and VEGF-D are considered novel growth factors that potentially induce lymphangiogenesis and hyperplasia of lymphatic vessels. The aim of this study was to investigate whether the expressions of VEGF-C and VEGF-D are associated with the clinicophathologic factors, and particularly lymphatic invasion and lymph node metastasis, in early gastric cancers that’s invaded the submucosa.
Methods: Using immunohistochemical staining, we studied the VEGF-C and VEGF-D expressions in the gastric cancer specimens from 83 patients who underwent curative gastrectomy.
Results: The VEGF-C and VEGF-D immunoreactivity was mainly located in the cytoplasm of the tumor cells. There was a positive VEGF-C expression in 27 of 83 cases (32.5%). The VEGF-D positivity rate was lower than the VEGF-C positivity rate. VEGF-D was positive in 20 of 83 cases (24.0%). A VEGF-C positive expression was associated with lymphatic invasion (P=0.018) and lymph node metastasis (P=0.001). However, the expression of VEGF-D had no correlation with any of the clinicopathologic factors, including lymphatic invasion and lymph node metastasis.
Conclusion: The VEGF-C expression may have a role in lymph node metastasis of gastric cancer cells. The VEGF-C expression in tumor specimens may be a reliable marker for lymph node metastasis of early gastric cancer that’s invaded the submucosa.
Methods: Using immunohistochemical staining, we studied the VEGF-C and VEGF-D expressions in the gastric cancer specimens from 83 patients who underwent curative gastrectomy.
Results: The VEGF-C and VEGF-D immunoreactivity was mainly located in the cytoplasm of the tumor cells. There was a positive VEGF-C expression in 27 of 83 cases (32.5%). The VEGF-D positivity rate was lower than the VEGF-C positivity rate. VEGF-D was positive in 20 of 83 cases (24.0%). A VEGF-C positive expression was associated with lymphatic invasion (P=0.018) and lymph node metastasis (P=0.001). However, the expression of VEGF-D had no correlation with any of the clinicopathologic factors, including lymphatic invasion and lymph node metastasis.
Conclusion: The VEGF-C expression may have a role in lymph node metastasis of gastric cancer cells. The VEGF-C expression in tumor specimens may be a reliable marker for lymph node metastasis of early gastric cancer that’s invaded the submucosa.
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REFERENCES
참고문헌 (27)
참고문헌 신청
Noguchi Y , 2000 , Is gastric carcinoma different between Japan and the United States? , Cancer 89 : 2237 ~ 2246
Hundahl SA , 2000 , The National Cancer Data Base Report on poor survival of U.S. gastric carcinoma patients treated with gastrectomy: Fifth Edition American Joint Committee on Cancer staging, proximal disease, and the “different disease” hypothesis , Cancer 88 : 921 ~ 932
Inoue K , 1991 , Problems in the definition and treatment of early gastric cancer , Br J Surg 78 : 818 ~ 821
Ono H , 2006 , Early gastric cancer: diagnosis, pathology, treatment techniques and treatment outcomes , Eur J Gastroenterol Hepatol 18 : 863 ~ 866
Sano T , 2006 , Early gastric cancer: diagnosis and less invasive treatments , Scand J Surg 95 : 249 ~ 255
Hundahl SA , 2000 , The National Cancer Data Base Report on poor survival of U.S. gastric carcinoma patients treated with gastrectomy: Fifth Edition American Joint Committee on Cancer staging, proximal disease, and the “different disease” hypothesis , Cancer 88 : 921 ~ 932
Inoue K , 1991 , Problems in the definition and treatment of early gastric cancer , Br J Surg 78 : 818 ~ 821
Ono H , 2006 , Early gastric cancer: diagnosis, pathology, treatment techniques and treatment outcomes , Eur J Gastroenterol Hepatol 18 : 863 ~ 866
Sano T , 2006 , Early gastric cancer: diagnosis and less invasive treatments , Scand J Surg 95 : 249 ~ 255
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UCI(KEPA) : I410-ECN-0101-2013-514-002693767