지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.10
- 수록면
- 255 - 261 (7page)
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초록· 키워드
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Purpose: Patients with gallbladder cancer tend to have advanced, unresectable tumor at the time of presentation and they face a dismal prognosis in the absence of a standard chemotherapy regimen. This study was performed to evaluate the outcomes of patients with gallbladder cancer and who underwent postoperative gemcitabine-based chemotherapy.
Methods: From March of 2001 to February of 2008, a total of 27 patients underwent operation for gallbladder cancer. They underwent two types of gemcitabine-based chemotherapy. One type of regimen was the combined administration of gemcitabine 1,000 mg/㎡ and 5-fluorouracil 200 mg/㎡. The other one was combined administration of gemcitabine 1,000 mg/㎡ and cisplatin 70 mg/㎡.
Results: Among the 27 patients, 15 patients were treated with gemcitabine-based chemotherapy and 12 patients were treated with many kinds of the best supportive care without chemotherapy. The median survival was 29.1±2.7 months and 15.7±2.8 months, respectively. The median survival and disease free survival for the gemcitabine based chemotherapy group who received curative resection was 31.6±2.5 and 15.7±3.2 months, respectively. The median survival and disease free survival for the patients without chemotherapy after curative resection was 16.3±2.9 and 15.7±3.2 months, respectively.
Conclusion: Patients with gallbladder cancer and who received adjuvant gemcitabine-based chemotherapy had a relatively favorable prognosis. Especially, gemcitabine-based combination chemotherapy could be effective and acceptable for the treatment of gallbladder cancer patients who have undergone curative resection.
Methods: From March of 2001 to February of 2008, a total of 27 patients underwent operation for gallbladder cancer. They underwent two types of gemcitabine-based chemotherapy. One type of regimen was the combined administration of gemcitabine 1,000 mg/㎡ and 5-fluorouracil 200 mg/㎡. The other one was combined administration of gemcitabine 1,000 mg/㎡ and cisplatin 70 mg/㎡.
Results: Among the 27 patients, 15 patients were treated with gemcitabine-based chemotherapy and 12 patients were treated with many kinds of the best supportive care without chemotherapy. The median survival was 29.1±2.7 months and 15.7±2.8 months, respectively. The median survival and disease free survival for the gemcitabine based chemotherapy group who received curative resection was 31.6±2.5 and 15.7±3.2 months, respectively. The median survival and disease free survival for the patients without chemotherapy after curative resection was 16.3±2.9 and 15.7±3.2 months, respectively.
Conclusion: Patients with gallbladder cancer and who received adjuvant gemcitabine-based chemotherapy had a relatively favorable prognosis. Especially, gemcitabine-based combination chemotherapy could be effective and acceptable for the treatment of gallbladder cancer patients who have undergone curative resection.
목차
서론
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결론
REFERENCES
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Muratore A / 2000 / Radical surgery for gallbladder cancer: current option / Eur J Surg Oncol 26 : 438 ~ 443
2. [학술지(정기간행물)] - Yamaguchi K / 1997 / Retrospective analysis of 70 operations for gallbladder carcinoma / Br J Surg 84 : 200 ~ 204
3. [학술지(정기간행물)] - Shimada H / 1997 / The role of lymph node dissection in the treatment of gallbladder carcinoma cancer / Cancer 79 : 892 ~ 899
4. [학술지(정기간행물)] - Lim SB / 1998 / A clinical study of prognostic factors in gallbladder cancer / J Korean Surg Soc 55 : 120 ~ 131
5. [학술지(정기간행물)] - Grobmyer SR / 2004 / Gallbladder cancer in the twentieth century: single institution's experience / World J Surg 28 : 47 ~ 49
2. [학술지(정기간행물)] - Yamaguchi K / 1997 / Retrospective analysis of 70 operations for gallbladder carcinoma / Br J Surg 84 : 200 ~ 204
3. [학술지(정기간행물)] - Shimada H / 1997 / The role of lymph node dissection in the treatment of gallbladder carcinoma cancer / Cancer 79 : 892 ~ 899
4. [학술지(정기간행물)] - Lim SB / 1998 / A clinical study of prognostic factors in gallbladder cancer / J Korean Surg Soc 55 : 120 ~ 131
5. [학술지(정기간행물)] - Grobmyer SR / 2004 / Gallbladder cancer in the twentieth century: single institution's experience / World J Surg 28 : 47 ~ 49
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