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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 173 - 177 (5page)
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PURPOSE: The prognosis of patients with advanced non-small-cell lung cancer (NSCLC) is extremely poor. Many prospective randomized trials on patients with advanced NSCLC suggested systemic chemotherapy improves both the survival and quality of life. A phase II trial was conducted to evaluate the efficacy and safety profile of the combination chemotherapy of gemcitabine and cisplatin in advanced NSCLC. MATERIALS AND METHODS: Forty-four patients with locally advanced or metastatic NSCLC were enrolled. The patients received a cisplatin, 75 mg/m2, infusion over 30 minutes on days 1, followed by a gemcitabine, 1,250 mg/m2, infusion over 30 minutes on days 1 and 8 every 3 weeks. RESULTS: The median age of the patients was 64 years (range: 27~75). Forty-one patients were assessable for response and toxicity analyses. The overall response rate was 53.6%, but with no complete remissions. The median time to progression was 5.6 months (range: 1~15.4). The median survival was 14.2 months (95% confidence interval (CI), 13.8~22.5). A total of 179 cycles were administered, with a median of 4 cycles of chemotherapy, ranging from 2 to 9 cycles. The most common hematological toxicities were NCI grades 3/4 neutropenia (24%) and thrombocytopenia (7.8%). The most common non-hematological toxicity was fatigue (42.4%). There were no life-threatening toxicity or treatment related mortalities. The median duration of follow up was 9.4 months, ranging from 1.6 to 30.3 months. CONCLUSION: In this trial, the combination of gemcitabine and cisplatin showed significant activity, with acceptable and manageable toxicities as a first-line regimen for patients with advanced NSCLC. (Cancer Res Treat. 2004;36:173-177)
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참고문헌 (23)
참고문헌 신청
/ 1991 / Chemotherapy fornon-small-cell lung cancer 99 : 1326 ~ 1328
/ 1992 / Chemotherapy of lung cancer 327 : 1434 ~ 1441
/ 1993 / Chemotherapy for advancednon-small cell lung cancer:how much benefit is enough 11 : 1866 ~ 1872
/ 1994 / The treatment of non-small cell lung cancer:Current perspectives and controversies,future directions 21 : 49 ~ 59
/ 1995 / Chemotherapyin non-small cell lung cancer:A meta-analysis usingupdated data on individual patients from 52 randomisedclinical trials 311 : 899 ~ 909
/ 1992 / Chemotherapy of lung cancer 327 : 1434 ~ 1441
/ 1993 / Chemotherapy for advancednon-small cell lung cancer:how much benefit is enough 11 : 1866 ~ 1872
/ 1994 / The treatment of non-small cell lung cancer:Current perspectives and controversies,future directions 21 : 49 ~ 59
/ 1995 / Chemotherapyin non-small cell lung cancer:A meta-analysis usingupdated data on individual patients from 52 randomisedclinical trials 311 : 899 ~ 909
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