지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.3
- 수록면
- 157 - 164 (8page)
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초록· 키워드
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Purpose: Papillary Thyroid Microcarcinoma (PTMC) is rapidly increasing due to increased interests in the public health care system and improvements in ultrasonographic instruments and fine-needle-aspiration technique. The aim of this study is to investigate relationships between clinicopathologic features and molecular markers of PTMC and to help in developing therapeutic strategies in PTMC.
Methods: Tissue samples from patients with 38 PTMC and 21 benign thyroid tumors that were operated on from Jan. 2006 to Nov. 2008 were used to make microarrays and immunohistochemical staining for ER-α, E-CD, VEGF, MMP-2, MMP-9, and HIF-1α were performed. Clinicopathologic features of each immunohistochemical staining group were analyzed retrospectively.
Results: There is no immunohistochemistry staining in cases with benign thyroid lesions. The expression rate of ER-α, E-CD, VEGF, MMP-2, MMP-9, and HIF-1α in PTMC group was 66%, 58%, 82%, 66%, 71% and 63%, respectively. Bilateral tumor was statistically significant (48.0% vs 7.7%, P=0.015) related to MMP-2(＋) PTMC group than in MMP-2(?) group. Bilateral tumor (44.4% vs 9.1%, P=0.060) and lymphovascular invasion (25.9% vs 0%, P=0.084) seemed to have greater relation to MMP-9(＋) PTMC group than to MMP-9(?) group, but there is no statistically significant difference. Bilateral tumor (50.0% vs 7.1%, P=0.012), lymph node metastasis (45.8% vs 0%, P=0.003) and lymphovascular invasion (29.2% vs 0%, P=0.033) were significantly related to HIF-1α (＋) PTMC group compared to HIF-1α(?) group.
Conclusion: Our findings suggest that MMP-2, MMP-9 and HIF-1α expression could be used as a prognostic marker in PTMC. Larger studies are needed to assess its prognostic value in PTMC.
Methods: Tissue samples from patients with 38 PTMC and 21 benign thyroid tumors that were operated on from Jan. 2006 to Nov. 2008 were used to make microarrays and immunohistochemical staining for ER-α, E-CD, VEGF, MMP-2, MMP-9, and HIF-1α were performed. Clinicopathologic features of each immunohistochemical staining group were analyzed retrospectively.
Results: There is no immunohistochemistry staining in cases with benign thyroid lesions. The expression rate of ER-α, E-CD, VEGF, MMP-2, MMP-9, and HIF-1α in PTMC group was 66%, 58%, 82%, 66%, 71% and 63%, respectively. Bilateral tumor was statistically significant (48.0% vs 7.7%, P=0.015) related to MMP-2(＋) PTMC group than in MMP-2(?) group. Bilateral tumor (44.4% vs 9.1%, P=0.060) and lymphovascular invasion (25.9% vs 0%, P=0.084) seemed to have greater relation to MMP-9(＋) PTMC group than to MMP-9(?) group, but there is no statistically significant difference. Bilateral tumor (50.0% vs 7.1%, P=0.012), lymph node metastasis (45.8% vs 0%, P=0.003) and lymphovascular invasion (29.2% vs 0%, P=0.033) were significantly related to HIF-1α (＋) PTMC group compared to HIF-1α(?) group.
Conclusion: Our findings suggest that MMP-2, MMP-9 and HIF-1α expression could be used as a prognostic marker in PTMC. Larger studies are needed to assess its prognostic value in PTMC.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Davies L / 2006 / Increasing incidence of thyroid cancer in the United States, 1973-2002 / JAMA 295 : 2164 ~ 2167
2. [보고서] - Ministry of Health and Welfare / 2007 / Annual Report of the Korea Central Cancer Registry 2002
3. [학술지(정기간행물)] - Sherman SI / 2003 / Thyroid carcinoma / Lancet 361 : 501 ~ 511
4. [학술지(정기간행물)] - Hodgson NC / 2004 / Thyroid cancer: is the incidence still increasing? / Ann Surg Oncol 11 : 1093 ~ 1097
5. [학술지(정기간행물)] - 최윤정 / 2008 / Prevalence of Thyroid Cancer at a Medical Screening Center: Pathological Features of Screen-detected Thyroid Carcinomas / Yonsei Medical Journal 49 (5) : 748 ~ 756
2. [보고서] - Ministry of Health and Welfare / 2007 / Annual Report of the Korea Central Cancer Registry 2002
3. [학술지(정기간행물)] - Sherman SI / 2003 / Thyroid carcinoma / Lancet 361 : 501 ~ 511
4. [학술지(정기간행물)] - Hodgson NC / 2004 / Thyroid cancer: is the incidence still increasing? / Ann Surg Oncol 11 : 1093 ~ 1097
5. [학술지(정기간행물)] - 최윤정 / 2008 / Prevalence of Thyroid Cancer at a Medical Screening Center: Pathological Features of Screen-detected Thyroid Carcinomas / Yonsei Medical Journal 49 (5) : 748 ~ 756
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UCI(KEPA) : I410-ECN-0101-2013-514-002679723