지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.12
- 수록면
- 459 - 464 (6page)
이용수
초록· 키워드
오류제보하기
Purpose: Galectin 3 is a β-galactoside binding protein that is involved in various biological processes such as cell adhesion, migration, cell growth, tumor progression and metastasis. Although the precise acting mechanisms of Galectin 3 are unclear, it have been reported that the expression of Galectin 3 may related to tumor progression and metastasis. We investigated the immunohistochemical expression of Galectin 3 in 57 cases of benign and malignant breast neoplasm to evaluate the relation of a Galectin 3 expression to malignancy of breast neoplasm and the acting mechanism of Galectin 3.
Methods: Twenty fibroadenomas, 7 intraductal papillomas, 10 intraductal carcinomas and 20 invasive ductal carcinomas were studied. Immunostaining of Galectin 3 was evaluated in comparison with that of the internal controls, and the intensity of immunostaining was semiquantitatively graded on an intensity scale of 0 to 3.
Results: The normal ductal epithelium of the breast showed strong immunoreactivity with an intensity 2 to 3. The staining gradually and significantly decreased in accordance with the histopathological type and tumor progression from a fibroadenoma, intraductal papilloma, ductal carcinoma in situ and invasive ductal carcinoma (P＜0.001). In particular, the expression of galection-3 was prominently decreased in invasive ductal carcinoma.
Conclusion: The galectin-3 expression pattern suggests that progression from benign breast tumor to malignant breast tumor leads to a reduced expression of galectin-3.
Methods: Twenty fibroadenomas, 7 intraductal papillomas, 10 intraductal carcinomas and 20 invasive ductal carcinomas were studied. Immunostaining of Galectin 3 was evaluated in comparison with that of the internal controls, and the intensity of immunostaining was semiquantitatively graded on an intensity scale of 0 to 3.
Results: The normal ductal epithelium of the breast showed strong immunoreactivity with an intensity 2 to 3. The staining gradually and significantly decreased in accordance with the histopathological type and tumor progression from a fibroadenoma, intraductal papilloma, ductal carcinoma in situ and invasive ductal carcinoma (P＜0.001). In particular, the expression of galection-3 was prominently decreased in invasive ductal carcinoma.
Conclusion: The galectin-3 expression pattern suggests that progression from benign breast tumor to malignant breast tumor leads to a reduced expression of galectin-3.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Barondes SH / 1994 / Galectins: a family of animal beta-galactoside-binding lectins / Cell 76 : 597 ~ 598
2. [학술대회논문] - Cherayil BJ / 1990 / Molecular cloning of a human macrophage lectin specific for galactose / Proc Natl Acad Sci USA 87 : 7324 ~ 7328
3. [학술지(정기간행물)] - Ho MK / 1982 / Mac-2, a novel 32,000 Mr mouse macrophage subpopulation-specific antigen defined by monoclonal antibodies / J Immunol 128 : 1221 ~ 1228
4. [학술지(정기간행물)] - Schoeppner HL / 1995 / Expression of an endogenous galactose-binding lectin correlates with neoplastic progression in the colon / Cancer 75 : 2818 ~ 2826
5. [학술지(정기간행물)] - Shalom-Feuerstein R / 2005 / Galectin-3 regulates a molecular switch from N-Ras to K-Ras usage in human breast carcinoma cells / Cancer Res 65 : 7292 ~ 7300
2. [학술대회논문] - Cherayil BJ / 1990 / Molecular cloning of a human macrophage lectin specific for galactose / Proc Natl Acad Sci USA 87 : 7324 ~ 7328
3. [학술지(정기간행물)] - Ho MK / 1982 / Mac-2, a novel 32,000 Mr mouse macrophage subpopulation-specific antigen defined by monoclonal antibodies / J Immunol 128 : 1221 ~ 1228
4. [학술지(정기간행물)] - Schoeppner HL / 1995 / Expression of an endogenous galactose-binding lectin correlates with neoplastic progression in the colon / Cancer 75 : 2818 ~ 2826
5. [학술지(정기간행물)] - Shalom-Feuerstein R / 2005 / Galectin-3 regulates a molecular switch from N-Ras to K-Ras usage in human breast carcinoma cells / Cancer Res 65 : 7292 ~ 7300
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Expression of Galectin-3, a Beta-Galactoside Binding Protein, in Dendritic Cells
Immune Network
2005 .06
-
Roles of Galectin-7 in Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Galectin-8 Expression in Laryngeal Squamous Cell Carcinoma
Clinical and Experimental Otorhinolaryngology
2009 .01
-
Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia
Journal of Pathology and Translational Medicine
2015 .01
-
Galectin-9 Acts as a Prognostic Factor with Antimetastatic Potential in Hepatocellular Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Galectin-1, -3, -7 Expressions in Congenital and Acquired Pediatric Cholesteatomas Compared to External Auditory Canal Skin
Clinical and Experimental Otorhinolaryngology
2012 .01
-
갑상선 종양에서의 Galectin-3 발현에 관한 분석
대한외과학회 학술대회 초록집
2002 .10
-
수술 전 세침흡입 세포검사에서 악성감별이 어려운 갑상선 결절에 대한 Galectin-3 면역조직화학 염색의 진단적 유용성
Annals of Surgical Treatment and Research
2004 .06
-
갑상선유두암에서 Galectin-3, p53, Ki-67 단백질의 발현과 임상학적 의미
Annals of Surgical Treatment and Research
2009 .07
-
Decreased Galectin-3 and -7 Expressions in Old-Aged Skin and Their Differential Expression in Skin Equivalents
Annals of Dermatology
2018 .01
-
비소세포폐암종에서 Galectin-3 단백 발현의 의의
Journal of Pathology and Translational Medicine
2006 .01
-
Increased Expression of Galectin-9 in Acute Experimental Autoimmune Encephalomyelitis
한국실험동물학회 학술발표대회 논문집
2014 .02
-
Galectin-3-independent Down-regulation of GABABR1 due to Treatment with Korean Herbal Extract HAD-B Reduces Proliferation of Human Colon Cancer Cells
Journal of Pharmacopuncture
2012 .01
-
갑상선종양에서 Galectin-3의 면역조직화학적 발현에 관한 연구
대한이비인후-두경부외과학회지
2005 .01
-
갑상선 종양에서 Galectin-3 발현의 임상적 의의
대한이비인후-두경부외과학회지
2006 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-514-002682868