갑상선 종양에서 Galectin-3 발현의 임상적 의의

노영수; 안회영; 신형식; 조성진; 김진환; 오소정; 한동혁

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자료유형: 학술저널

저자정보: 노영수 안회영 신형식 조성진 김진환 오소정 한동혁

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제8호

발행연도: 2006.1

수록면: 812 - 816 (5page)

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Background and Objectives：Galectin-3 is a beta-galactoside binding protein, of which the major function is not fully elucidatedin malignant tumor. However, galectin-3 is expressed in epithelial cells and contributes to the progression of cancer. Althoughgalectin-3 is expressed in a variety of tissues and plays important roles in malignant transformation or tumor progression,the study on its expression related to clinicopathological parameters in thyroid tumor is rare. So, the present study aims to findout the clinical significance of galectin-3 in thyroid tumor. Subjects and Method：We assessed mRNA and protein expressionsof the galectin-3 gene by means of the RT-PCR method and immunohistochemical staining in 100 cases of thyroid tumors (50papillary carcinomas, 10 follicular carcinomas, 20 follicular adenomas, 20 nodular hyperplasia). The expression of galectin-3 iscompared with the clinical prognostic factors of thyroid papillary cancer. Results：Using RT-PCR, galectin-3 mRNA was detectedin 41 (82%) in papillary carcinoma, 6 (60%) in follicular carcinoma, 8 (40%) in follicular adenoma and 9 (45%) in nodularhyperplasia cases. Using immunohistochemical staining, galectin-3 protein expressions were detected in 46 (92%), 7(70%), 3 (15%) and 1 (5%). The expressions of the galectin-3 mRNA and protein were significantly recognized in thyroid papillarycarcinoma. However, the galectin-3 mRNA and protein over-expression is not significantly correlated with the clinicalprognostic factors of thyroid papillary carcinoma. Conclusion：These results suggest that galectin-3 expression may be associatedwith thyroid papillary carcinoma development. (Korean J Otolaryngol 2006;49:812-6)

#갑상선 종양·Galectin-3. #Thyroid tumor·Galectin-3.

참고문헌 (11)

참고문헌 신청

/ / Decreased expression of Mac-2 and loss of its nuclear localization are associatedwith the neoplastics progression of colon carcinoma : 3466 ~ 70

/ 1996 / Decreased expression of galectin-3 is associated with progressionof human breast cancer 179 : 43 ~ 48

/ 1996 / Expression of the 67-kD laminin receptor galectin-1 and galectin-3 in advanced human uterine adenocarcinoma 27 : 1185 ~ 1191

/ 1997 / Galectin-3 and laminin expression in neoplastic andnon-neoplastic thyroid tissue 181 : 80 ~ 86

/ 1997 / Telomerase activity in the differential diagnosis of papillary carcinomaof the thyroid 122 : 1137 ~ 1140

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