지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.10
- 수록면
- 315 - 320 (6page)
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초록· 키워드
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Purpose: Angiogenesis and lymphangiogenesis play important roles in the growth, progression and metastasis of colon cancer. We performed this study in order to investigate the significance of the CD31 and D2-40 expressions as prognostic factors in colon cancer.
Methods: The angiogenic and lymphagiogenic microvessel density was assessed by immunohistochemical staining of CD31 and D2-40 on samples that were resected from 66 patients with colorectal cancer.
Results: Strong correlation was observed between the CD31 microvessel density and being positive for having tumor emboli and lymph node metastasis (P=0.001, P=0.003). The D2-40 lymphatic vessel density was correlated with being positive for having tumor emboli (P=0.0001), the depth of invasion (P=0.0001), lymph node metastasis (P= 0.0001) and the cancer stage (P=0.0001). The D2-40 lymphatic vessel density was also correlated with the CD31 count (P=0.003).
Conclusion: These results suggested that the CD31 and D2-40 expressions are useful predictors of lymph node metastasis and they are prognostic factors for colon cancer.
Methods: The angiogenic and lymphagiogenic microvessel density was assessed by immunohistochemical staining of CD31 and D2-40 on samples that were resected from 66 patients with colorectal cancer.
Results: Strong correlation was observed between the CD31 microvessel density and being positive for having tumor emboli and lymph node metastasis (P=0.001, P=0.003). The D2-40 lymphatic vessel density was correlated with being positive for having tumor emboli (P=0.0001), the depth of invasion (P=0.0001), lymph node metastasis (P= 0.0001) and the cancer stage (P=0.0001). The D2-40 lymphatic vessel density was also correlated with the CD31 count (P=0.003).
Conclusion: These results suggested that the CD31 and D2-40 expressions are useful predictors of lymph node metastasis and they are prognostic factors for colon cancer.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Locopo N / 1998 / Clinical significance of angiogenic factors in breast cancer / Breast Cancer Res Treat 52 : 159 ~ 173
2. [학술지(정기간행물)] - Leibovich SJ / 1987 / Macrophage-induced angiogenesis is mediated by tumor necrosis factor-alpha / Nature 329 : 630 ~ 632
3. [학술지(정기간행물)] - Keck PJ / 1989 / Vascular permeability factor, an endothelial cell mitogen related to PDGF / Science 245 : 1309 ~ 1311
4. [학술지(정기간행물)] - Uzzan B / 2004 / Microvessel dendity as a prognostic factor in women with breast cancer: a systemic review of the literature and metaanalysis / Cancer Res 64 : 2941 ~ 2955
5. [학술지(정기간행물)] - Maula SM / 2002 / Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region / Cancer Res 63 : 1920 ~ 1926
2. [학술지(정기간행물)] - Leibovich SJ / 1987 / Macrophage-induced angiogenesis is mediated by tumor necrosis factor-alpha / Nature 329 : 630 ~ 632
3. [학술지(정기간행물)] - Keck PJ / 1989 / Vascular permeability factor, an endothelial cell mitogen related to PDGF / Science 245 : 1309 ~ 1311
4. [학술지(정기간행물)] - Uzzan B / 2004 / Microvessel dendity as a prognostic factor in women with breast cancer: a systemic review of the literature and metaanalysis / Cancer Res 64 : 2941 ~ 2955
5. [학술지(정기간행물)] - Maula SM / 2002 / Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region / Cancer Res 63 : 1920 ~ 1926
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UCI(KEPA) : I410-ECN-0101-2013-514-002670997