지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.5
- 수록면
- 351 - 357 (7page)
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Purpose: Gastric variceal bleeding in cirrhotic patient is an emergent, life threatening disease of which the adequate treatment is still in dispute. The periesophagogastric devascularization (PD) would be the alternative operative procedure. The aim of this study is to evaluate the safety and long-term results of PD for the gastric fundal variceal bleeding.
Methods: A retrospective analysis was made of fifty-two patients with gastric variceal bleeding who underwent PD with or without fundectomy from August 1994 to March 2006. We evaluated the clinical characteristics, operative morbidity, mortality and long-term follow up results.
Results: The operative morbidity was 34.9% and overall mortality was 17.3%. The Child-Pugh classification at operation, the number of previous varix bleeding episode, the success of preoperative intervention, splenectomy, esophageal transection, and ongoing bleeding at operation had a significant effect on postoperative mortality. Most common cause of postoperative death was hepatic failure. Child-Pugh classification and esophageal transection were significant risk factor for postoperative mortality comparing before and after year 2001. During the mean follow-up period of 33.58±27.08 months, there was no recurrent bleeding from gastric varices. The cumulative 5-year survival rate was 64.1%. 0f 14 patients deceased, 6 patients died of hepatocellular carcinoma. Not only there was no death caused by recurrent variceal bleeding, but there was no recurrent gastric variceal bleeding. Hepatic functional reserve and concomitant hepatocellular carcinoma were the most important prognostic factors in the long term survival by multiple regression analysis.
Conclusion: We concluded that PD reached both low postoperative mortality and recurrent bleeding rate with good long-term survival. So it could be one of the most effective treatment for the gastric fundal variceal bleeding.
Methods: A retrospective analysis was made of fifty-two patients with gastric variceal bleeding who underwent PD with or without fundectomy from August 1994 to March 2006. We evaluated the clinical characteristics, operative morbidity, mortality and long-term follow up results.
Results: The operative morbidity was 34.9% and overall mortality was 17.3%. The Child-Pugh classification at operation, the number of previous varix bleeding episode, the success of preoperative intervention, splenectomy, esophageal transection, and ongoing bleeding at operation had a significant effect on postoperative mortality. Most common cause of postoperative death was hepatic failure. Child-Pugh classification and esophageal transection were significant risk factor for postoperative mortality comparing before and after year 2001. During the mean follow-up period of 33.58±27.08 months, there was no recurrent bleeding from gastric varices. The cumulative 5-year survival rate was 64.1%. 0f 14 patients deceased, 6 patients died of hepatocellular carcinoma. Not only there was no death caused by recurrent variceal bleeding, but there was no recurrent gastric variceal bleeding. Hepatic functional reserve and concomitant hepatocellular carcinoma were the most important prognostic factors in the long term survival by multiple regression analysis.
Conclusion: We concluded that PD reached both low postoperative mortality and recurrent bleeding rate with good long-term survival. So it could be one of the most effective treatment for the gastric fundal variceal bleeding.
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REFERENCES
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Sarin SK / 1992 / Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients / Hepatology 16 : 1343 ~ 1349
2. [학술지(정기간행물)] - Sarin SK / 1988 / Endoscopic sclerotherapy in the treatment of gastric varices / Br J Surg 75 : 747 ~ 750
3. [학술지(정기간행물)] - Mercado MA / 1993 / An alternate low risk technique for esophageal transection in the Sugiura-Futagawa procedure / Am Surg 59 : 461 ~ 464
4. [학술지(정기간행물)] - Ohnishi K / 1985 / Interrelationship between type of spontaneous portal systemic shunt and portal vein pressure in patients with liver disease / Am J Gastroenterol 80 : 561 ~
5. [학술지(정기간행물)] - Watanabe K / 1971 / Portal hemodynamics in patients with gastric varice / Gastroenterol 68 : 721 ~
2. [학술지(정기간행물)] - Sarin SK / 1988 / Endoscopic sclerotherapy in the treatment of gastric varices / Br J Surg 75 : 747 ~ 750
3. [학술지(정기간행물)] - Mercado MA / 1993 / An alternate low risk technique for esophageal transection in the Sugiura-Futagawa procedure / Am Surg 59 : 461 ~ 464
4. [학술지(정기간행물)] - Ohnishi K / 1985 / Interrelationship between type of spontaneous portal systemic shunt and portal vein pressure in patients with liver disease / Am J Gastroenterol 80 : 561 ~
5. [학술지(정기간행물)] - Watanabe K / 1971 / Portal hemodynamics in patients with gastric varice / Gastroenterol 68 : 721 ~
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UCI(KEPA) : I410-ECN-0101-2013-514-002673569