지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.4
- 수록면
- 263 - 269 (7page)
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초록· 키워드
오류제보하기
Purpose: Sentinel lymph node biopsy has emerged as a new standard method of treatment in small-sized breast cancer and has allowed the elimination of unnecessary axillary lymph node dissection in patients with negative axillary lymph nodes metastasis. In sentinel lymph node biopsy, pathologic analysis can be scrutinized and accurate stage-diagnosis can be made with the methods of serial sectioning and immunohistochemical staining on routine basis. In this study, we tried to evaluate the accuracy of sentinel lymph node biopsy.
Methods: We evaluated 500 cases of sentinel lymph node biopsy operated at Samsung Medical Center between October 1995 and February 2004. Cases were categorized in 2 groups: cases operated during the period of learning curve (October 1995∼December 1999) and the period of clinical application (January 2000∼February 2004).
Results: Overall failure rate and false negative rate of sentinel node biopsy were 9% and 14.7% respectively. The failure rate of the period of learning curve and the period of clinical application were 15.3% and 5.6% respectively (P＜0.01). In sentinel lymph node detection, combined blue dye and radioisotope method was superior to blue dye or radioisotope method. About 40% of lymph node metastases were found in patients with tumors more than 2 ㎝ in size. Clinical findings including previous biopsy, multiple tumor, neo- adjuvant chemotherapy, obesity and old age were not absolute contraindications for sentinel node biopsy.
Conclusion: Sentinel lymph node biopsy can be an accurate and reliable method to examine the status of axillary nodes in a small breast cancer.
Methods: We evaluated 500 cases of sentinel lymph node biopsy operated at Samsung Medical Center between October 1995 and February 2004. Cases were categorized in 2 groups: cases operated during the period of learning curve (October 1995∼December 1999) and the period of clinical application (January 2000∼February 2004).
Results: Overall failure rate and false negative rate of sentinel node biopsy were 9% and 14.7% respectively. The failure rate of the period of learning curve and the period of clinical application were 15.3% and 5.6% respectively (P＜0.01). In sentinel lymph node detection, combined blue dye and radioisotope method was superior to blue dye or radioisotope method. About 40% of lymph node metastases were found in patients with tumors more than 2 ㎝ in size. Clinical findings including previous biopsy, multiple tumor, neo- adjuvant chemotherapy, obesity and old age were not absolute contraindications for sentinel node biopsy.
Conclusion: Sentinel lymph node biopsy can be an accurate and reliable method to examine the status of axillary nodes in a small breast cancer.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Fisher B / 2002 / Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer / N Engl J Med 347 : 1233 ~ 1241
2. [학술지(정기간행물)] - Veronesi U / 2002 / Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer / N Engl J Med 347 : 1227 ~ 1232
3. [학술지(정기간행물)] - Giuliano AE / 1994 / Lymphatic mapping and sentinel lymphadenectomy for breast cancer / Ann Surg 220 : 391 ~ 398
4. [학술지(정기간행물)] - Yang JH / 1997 / The significance of sentinel node biopsy in breast cancer surgery / J Korean Surg Soc 52 : 940 ~ 948
5. [학술지(정기간행물)] - Veronesi U / 2003 / A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer / N Engl J Med 349 : 546 ~ 553
2. [학술지(정기간행물)] - Veronesi U / 2002 / Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer / N Engl J Med 347 : 1227 ~ 1232
3. [학술지(정기간행물)] - Giuliano AE / 1994 / Lymphatic mapping and sentinel lymphadenectomy for breast cancer / Ann Surg 220 : 391 ~ 398
4. [학술지(정기간행물)] - Yang JH / 1997 / The significance of sentinel node biopsy in breast cancer surgery / J Korean Surg Soc 52 : 940 ~ 948
5. [학술지(정기간행물)] - Veronesi U / 2003 / A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer / N Engl J Med 349 : 546 ~ 553
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UCI(KEPA) : I410-ECN-0101-2013-514-002673887