지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 222 - 231 (10page)
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초록· 키워드
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Purpose: Intrahepatic recurrent HCC has been classified according to location, the time to recurrence and the pattern of presentation. The purpose of this study is to classify intrahepatic recurrent HCCs into subgroups that have relatively similar recurrent patterns and to identify the risk factors for each recurrent type.
Methods: A total of 353 patients were retrospectively studied. Intrahepatic recurrent HCC was classified into nodular recurrence (<4 nodules; type I), multinodular-diffuse recurrence (≥4 nodules; type II) and infiltrative recurrence (type III). The cut-off time between early and late recurrence was chosen to be 12 months following hepatectomy.
Results: Among the 134 patients with only intrahepatic recurrence, 94 were type I, 27 were type II and 13 were type III. The median survival time following the recurrence of types I, II and III were 55, 16 and 8 months, respectively. As determined by multivariate analysis, perioperative transfusion and indocyanine green retention at 15 minutes (ICG R 15 >10%) were the independent risk factors for type I; an ICG R 15>10%, microvessel invasion and intrahepatic metastasis were the independent risk factors for type II; an ICG R 15>10% and microscopic portal vein invasion were the independent risk factors for type III. Multivariate analysis revealed that the prognosis of patients with IHR was associated with the recurrent types, the time to recurrence and the serum albumin level at the initial presentation. Following multivariate analysis, an ICG R 15>10% and intrahepatic metastasis were the independent risk factors for early type I recurrence; perioperative transfusion and a higher grade of hepatitis activity were the independent risk factors for late type I recurrence.
Conclusions: The recurrent types and the time to recurrence may help us to predict the cellular origin of intrahepatic recurrent HCC and the prognosis of the patients who suffer with intrahepatic recurrent HCC.
Methods: A total of 353 patients were retrospectively studied. Intrahepatic recurrent HCC was classified into nodular recurrence (<4 nodules; type I), multinodular-diffuse recurrence (≥4 nodules; type II) and infiltrative recurrence (type III). The cut-off time between early and late recurrence was chosen to be 12 months following hepatectomy.
Results: Among the 134 patients with only intrahepatic recurrence, 94 were type I, 27 were type II and 13 were type III. The median survival time following the recurrence of types I, II and III were 55, 16 and 8 months, respectively. As determined by multivariate analysis, perioperative transfusion and indocyanine green retention at 15 minutes (ICG R 15 >10%) were the independent risk factors for type I; an ICG R 15>10%, microvessel invasion and intrahepatic metastasis were the independent risk factors for type II; an ICG R 15>10% and microscopic portal vein invasion were the independent risk factors for type III. Multivariate analysis revealed that the prognosis of patients with IHR was associated with the recurrent types, the time to recurrence and the serum albumin level at the initial presentation. Following multivariate analysis, an ICG R 15>10% and intrahepatic metastasis were the independent risk factors for early type I recurrence; perioperative transfusion and a higher grade of hepatitis activity were the independent risk factors for late type I recurrence.
Conclusions: The recurrent types and the time to recurrence may help us to predict the cellular origin of intrahepatic recurrent HCC and the prognosis of the patients who suffer with intrahepatic recurrent HCC.
목차
서론
대상과 방법
결과
고찰
참고문헌
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Torzilli G / 1999 / No-mortality liver resection for hepatocellular carcinoma in cirrhotic and noncirrhotic patients: is there a way? A prospective analysis of our approach / Arch Surg 134 : 984 ~ 992
2. [학술지(정기간행물)] - Poon RT / 2001 / Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years / Ann Surg 234 : 63 ~ 70
3. [학술지(정기간행물)] - Yeh CN / 2003 / Predictors of long-term disease-free survival after resection of hepatocellular carcinoma: two decades of experience at Chang Gung Memorial Hospital / Ann Surg Oncol 10 : 916 ~ 921
4. [학술지(정기간행물)] - Tung-Ping Poon R / 2000 / Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma / Ann Surg 232 : 10 ~ 24
5. [학술지(정기간행물)] - Poon RT / 2000 / Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma / Cancer 89 : 500 ~ 507
2. [학술지(정기간행물)] - Poon RT / 2001 / Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years / Ann Surg 234 : 63 ~ 70
3. [학술지(정기간행물)] - Yeh CN / 2003 / Predictors of long-term disease-free survival after resection of hepatocellular carcinoma: two decades of experience at Chang Gung Memorial Hospital / Ann Surg Oncol 10 : 916 ~ 921
4. [학술지(정기간행물)] - Tung-Ping Poon R / 2000 / Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma / Ann Surg 232 : 10 ~ 24
5. [학술지(정기간행물)] - Poon RT / 2000 / Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma / Cancer 89 : 500 ~ 507
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UCI(KEPA) : I410-ECN-0101-2014-514-001253894