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Effects of Hizikia fusiforme Extracts on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes
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논문 기본 정보

Type
Academic journal
Author
Eun Ok Choi (Anti-aging Research Center) Hyang Suk Kim (Anti-aging Research Center) Min Ho Han Yung Hyun Choi (Anti-aging Research Center) Byung Woo Kim (Blue-Bio Industry Regional Innovation center) Jinah Hwang (Myongji University) Hye Jin Hwang (Blue-Bio Industry Regional Innovation center)
Journal
Korean Society Of Life Science Journal of Life Science Vol.22 No.10 KCI Accredited Journals
Published
2012.10
Pages
1,399 - 1,406 (8page)

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Effects of Hizikia fusiforme Extracts on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes
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The present study was conducted to evaluate the effects of various extracts of Hizikia fusiforme on the anti-obesity effects in 3T3-L1 preadipocytes. We used H. fusiforme extracts from ethanol (EEHF), dichloromethane (CFHF), ethyl acetate (EAFHF), butanol (BFHF), and water (WFHF). Treatment with these extracts significantly suppressed terminal differentiation of 3T3-L1 preadipocytes in a dose-dependent manner as confirmed by a decrease in lipid droplet content through Oil Red O staining; this effect was higher in WFHF than in other extracts. The concentrations of cellular triglyceride were also reduced in 3T3-L1 cells by exposure with these extracts, especially when compared with the controls. Treatment with 200 μg/ml of WFHF and CFHF caused approximately 42.6% and 23.7% reduction, respectively. In addition, the extracts of H. fusiforme significantly reduced the expression levels of key pro-adipogenic transcription factors, including peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding proteins α (C/EBPα) and C/EBPβ as compared with controls. Accordingly, our data indicated that WFHF has a preeminent effect on inhibition of adipocyte differentiation among various extracts, and H. fusiforme extracts may be an ideal candidate for obesity relief.
#Hizikia fusiforme #3T3-L1 #obesity #adipogenesis #peroxisome proliferator-activated receptorγ (PPARγ) #CCAAT/enhancer binding protein (C/EBP)

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References (24)

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1. [학술지(정기간행물)] - Alessi, M. C. / 2003 / Adipose tissue and atherothrombosis / Pathophysiol. Haemost. Thromb 33 : 290 ~ 297 google schola 2. [학술지(정기간행물)] - Cao, Z. / 1991 / Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells / Genes Dev 5 : 1538 ~ 1552 google schola 3. [학술지(정기간행물)] - Chen, Z. / 2005 / Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms / Cell Metab 1 : 93 ~ 106 google schola 4. [학술대회논문] - Christy, R. J. / 1991 / CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes / Proc. Natl. Acad. Sci. USA 88 : 2593 ~ 2597 google schola 5. [학술지(정기간행물)] - Dobashi, K. / 1989 / Isolation and preliminary characterization of fucose-containing sulfated polysaccharides with blood-anticoagulant activity from the brown seaweed Hizikia fusiforme / Carbohydr. Res 194 : 315 ~ 320 google schola

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