Aerodynamic characteristics of a missile with strake-tail configuration is numerically simulated by using an inviscid CFD solver within angles of attack of 20 degrees. The results showed a good agreement with the wind-tunnel tests. A significant difference is oberserved in side force and pitching moment between roll attitudes of 0 and 45 degrees. It is found by component-breakdown analysis that the difference is attributed to the influence of the strake-tip vortex on the body and the tail fins.