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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objective: This study was performed to investigate the effect of Yagwan-cheunghyeoltang (YCT) on insulin secretion in RIN-m5F cells.
Methods: After treatment with various concentrations of YCT to RIN-m5F cells, cell viability, free radical-scavenging activity, SOD activity, and insulin secretion were measured. Additionally, insulin-related gene expressions were measured using real-time RT-PCR.
Results:
1. YCT didn"t show any influence on RIN-m5F cells viability.
2. YCT showed free radical-scavenging activity by 16% at 100㎍/㎖ of concentration.
3. YCT showed enhancement of SOD activity by 60% at 100㎍/㎖ of concentration.
4. YCT significantly increased insulin secretion in RIN-m5F cells in a dose-dependent manner.
5. YCT up-regulated INS-1, INS-2, IRS-1, IRS-2 and IRS-3 mRNA expressions compared to the control group.
6. YCT down-regulated INS-R, GCK, GLP-1R and GLP-2R mRNA expressions compared to the control group.
Conclusion: YCT has pharmaceutical properties enhancing insulin production and controlling glucose-associated metabolism, and could be a candidate for drug development after further research.
Methods: After treatment with various concentrations of YCT to RIN-m5F cells, cell viability, free radical-scavenging activity, SOD activity, and insulin secretion were measured. Additionally, insulin-related gene expressions were measured using real-time RT-PCR.
Results:
1. YCT didn"t show any influence on RIN-m5F cells viability.
2. YCT showed free radical-scavenging activity by 16% at 100㎍/㎖ of concentration.
3. YCT showed enhancement of SOD activity by 60% at 100㎍/㎖ of concentration.
4. YCT significantly increased insulin secretion in RIN-m5F cells in a dose-dependent manner.
5. YCT up-regulated INS-1, INS-2, IRS-1, IRS-2 and IRS-3 mRNA expressions compared to the control group.
6. YCT down-regulated INS-R, GCK, GLP-1R and GLP-2R mRNA expressions compared to the control group.
Conclusion: YCT has pharmaceutical properties enhancing insulin production and controlling glucose-associated metabolism, and could be a candidate for drug development after further research.
목차
서론
실험
결과
고찰
결론
참고문헌
참고문헌 (48)
참고문헌 신청
1. [단행본] - 가톨릭의과대학 내과학교실 / 2008 / Current principles and clinical practice of internal medicine 2nd ed / 군자출판사 : 823 ~
2. [인터넷자원] - 건강보험심사평가원 / / 질병. 수술병 진료정보
3. [학술지(정기간행물)] - Weir GC / 2004 / Five stages of evolving β-cell dysfunction during progression to diabetes / Diabetes 53 : S16 ~ S21
4. [학술지(정기간행물)] - Robertson RP / 2004 / Beta cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes / Diabetes 53 (1) : S119 ~ S124
5. [학술지(정기간행물)] - Lim SJ / 1995 / The effects of Korean wild vegetables on blood glucose levels and liver-muscle metabolism of streptozotocininduced diabetic rats / Korean Journal of Nutrition 28 : 585 ~ 594
2. [인터넷자원] - 건강보험심사평가원 / / 질병. 수술병 진료정보
3. [학술지(정기간행물)] - Weir GC / 2004 / Five stages of evolving β-cell dysfunction during progression to diabetes / Diabetes 53 : S16 ~ S21
4. [학술지(정기간행물)] - Robertson RP / 2004 / Beta cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes / Diabetes 53 (1) : S119 ~ S124
5. [학술지(정기간행물)] - Lim SJ / 1995 / The effects of Korean wild vegetables on blood glucose levels and liver-muscle metabolism of streptozotocininduced diabetic rats / Korean Journal of Nutrition 28 : 585 ~ 594
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UCI(KEPA) : I410-ECN-0101-2014-519-000283966