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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background : At high glucose levels in β-cells, cell viability and insulin secretion are decreased by glucotoxicity. Sopyung -tang(SPT) had an effect on blood glucose level decrease and antioxidant enzyme activities in streptozotocin-induced diabetic rats.
Objectives : This study performed a series of experiment to verify the effects of SPT extract on the cell viability, antioxidant enzyme activities, insulin secretion and insulin mRNA expression at hyperglycemic states of RIN-m5F.
Methods : After treatment at various concentrations of SPT added to the RIN-m5F cells, cell viability by MTT assay, free radical-scavenging activity, SOD activity and insulin secretion were measured. Additionally, insulin-related gene expression was measured using real-time RT-PCR.
Results : Compared to the control group, SPT extract showed considerable effects on RIN-m5F cell viability, DPPH radical-scavenging activity, superoxide dismutase (SOD) activity, insulin secretion and insulin-related gene expression.
Conclusions : This study showed that SPT extract has an effect on β-cell cell viability, insulin secretion and insulin -related gene expression. Thus, SPT extract may be used for treatment of diabetes and its complications. Further mechanism studies of SPT seem to be necessary on the glucotoxicity and oxidative stress.
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참고문헌 (28)
참고문헌 신청
Baynes JW / 1996 / The role of oxidative stress in diabetic complications / Curr Opin Endocrinol Diabetes Obes. 3 : 277 ~ 284
C. Guyton / 2002 / Text book of medical physiology / W.B. Saunders : 1033 ~ 1048
Frustaci A / 2000 / Myocardial cell death in human diabetes / Circ Res 87 : 1123 ~ 1132
Hunt JV / 1988 / Hydroxy radical production and autoxidative glycosylation: glucose autoxidation as the cause of protein damage in the experimental glycation model of diabete
Kahn SE / 2003 / The relative contributions of insulin resistance and β-cell dysfunction to the pathophysiology of type2 diabetes / Diabetologia 46 : 3 ~ 19
C. Guyton / 2002 / Text book of medical physiology / W.B. Saunders : 1033 ~ 1048
Frustaci A / 2000 / Myocardial cell death in human diabetes / Circ Res 87 : 1123 ~ 1132
Hunt JV / 1988 / Hydroxy radical production and autoxidative glycosylation: glucose autoxidation as the cause of protein damage in the experimental glycation model of diabete
Kahn SE / 2003 / The relative contributions of insulin resistance and β-cell dysfunction to the pathophysiology of type2 diabetes / Diabetologia 46 : 3 ~ 19
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