지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objective : The purpose of this study was to investigate the effects of skin application with Gelidium amansii extract on skin with deep second degree burns in mice.
Methods : BALB/c mice were divided into four groups: normal (NOR) group; burn-elicited mice (CON) group, Silmazine-treated mice after burn elicitation (ST) group, and Gelidium amansii-extract treated mice after burn elicitation (GT) group. To examine the skin recovery effect after burn, changes of burn area, angiogenesis and histologic structure were analyzed. To measure effect of edema regulation, matrix metalloproteinase-9 (MMP-9) was analyzed. To estimate the skin regenerative & stable effect, 5-bromo-2"-deoxyuridine (BrdU) and substance P were analyzed.
Results : 2 weeks later,
1. The size of burn area decreased in the GT and ST groups more than the CON group.
2. Alleviation of angiogenesis appeared in the GT and ST groups more than in the CON group.
3. Blood clot, epithelial cell hyperplasia, and inflammatory cell infiltration declined in the GT and ST groups more than in the CON group.
4. MMP-9, BrdU, and substance P positive reaction decreased in the GT and ST groups more than in the CON group
5. In the comparative study, the GT group was superior to the ST group.
Conclusion : The skin application of Gelidium amansii extract could lessen skin damage by the medium of regulation MMP-9 activation. This skin stabilization was induced in mice with deep second degree burns.
Methods : BALB/c mice were divided into four groups: normal (NOR) group; burn-elicited mice (CON) group, Silmazine-treated mice after burn elicitation (ST) group, and Gelidium amansii-extract treated mice after burn elicitation (GT) group. To examine the skin recovery effect after burn, changes of burn area, angiogenesis and histologic structure were analyzed. To measure effect of edema regulation, matrix metalloproteinase-9 (MMP-9) was analyzed. To estimate the skin regenerative & stable effect, 5-bromo-2"-deoxyuridine (BrdU) and substance P were analyzed.
Results : 2 weeks later,
1. The size of burn area decreased in the GT and ST groups more than the CON group.
2. Alleviation of angiogenesis appeared in the GT and ST groups more than in the CON group.
3. Blood clot, epithelial cell hyperplasia, and inflammatory cell infiltration declined in the GT and ST groups more than in the CON group.
4. MMP-9, BrdU, and substance P positive reaction decreased in the GT and ST groups more than in the CON group
5. In the comparative study, the GT group was superior to the ST group.
Conclusion : The skin application of Gelidium amansii extract could lessen skin damage by the medium of regulation MMP-9 activation. This skin stabilization was induced in mice with deep second degree burns.
목차
서론
실험 재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (39)
참고문헌 신청
1. [학술지(정기간행물)] - Gratzner HG / 1982 / Monoclonal antibody to 5-bromoand 5-iododexyuridi ne: a new reagent for detection of DNA replication / Science 218 : 474 ~ 475
2. [학술지(정기간행물)] - Pfaar O / 2009 / Pathophysiology of itching and sneezing in allergic rhinitis / Swiss med wkly 139 (3) : 35 ~ 40
3. [학술지(정기간행물)] - Jang YC / 2003 / Time Dependent Change of Neuropeptides in Human Burn Wound Healing and Scar Formation / Journal of Korean Burn Society 6 (2) : 124 ~ 133
4. [학술지(정기간행물)] - Fraser JF / 2004 / Cytotoxicity of topical antimicrobial agents used in burn wounds in Australasia / ANJ journal of surgery 74 (3) : 139 ~ 142
5. [학술지(정기간행물)] - 강민철 / 2009 / 실마진® 연고에 의한 알레르기성 접촉성 피부염 1예 / 대한피부과학회지 47 (6) : 710 ~ 713
2. [학술지(정기간행물)] - Pfaar O / 2009 / Pathophysiology of itching and sneezing in allergic rhinitis / Swiss med wkly 139 (3) : 35 ~ 40
3. [학술지(정기간행물)] - Jang YC / 2003 / Time Dependent Change of Neuropeptides in Human Burn Wound Healing and Scar Formation / Journal of Korean Burn Society 6 (2) : 124 ~ 133
4. [학술지(정기간행물)] - Fraser JF / 2004 / Cytotoxicity of topical antimicrobial agents used in burn wounds in Australasia / ANJ journal of surgery 74 (3) : 139 ~ 142
5. [학술지(정기간행물)] - 강민철 / 2009 / 실마진® 연고에 의한 알레르기성 접촉성 피부염 1예 / 대한피부과학회지 47 (6) : 710 ~ 713
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UCI(KEPA) : I410-ECN-0101-2014-519-000285384