지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 673 - 677 (5page)
이용수
초록· 키워드
오류제보하기
In order to verify the anti-inflammatory effects of Gelidium amansii, RAW264.7 macrophages were incubated with the extract of 70% ethanol solution (Ex), and activated with the endotoxin lipopolysaccharide (LPS). Ex inhibited the expression of the pro-inflammatory enzymes, including inducible nitric oxide (NO) synthase (iNOS) and cyclooxygenase-2 (COX-2), and the production of iNOS-mediated NO and COX-2-mediated prostglandin $E_2$ ($PGE_2$) production in a dose-dependent manner. Ex also reduced the release of the pro-inflammatory cytokines, including tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-1${\beta}$ (IL-1${\beta}$) and IL-6 in LPS-activated macrophages, The observed anti-inflammatory effects of Ex was associated with inactivation of the nuclear factor ${\kappa}B$ (NF-${\kappa}B$) that mediates the induction of iNOS, COX-2, TNF-${\alpha}$, IL-1${\beta}$, and IL-6. Further studies showed that Ex inactivated NF-${\kappa}B$ through inhibition of phosphorylation of the inhibitory ${\kappa}B$ ($l{\kappa}B$), Taken together, these results suggest that Gelidium amansii exerts anti-inflammatory effects by inhibiting the expression of pro-inflammatory enzymes and the secretion of pro-inflammatory cytokines via inactivation of NF-${\kappa}B$ and/or $l{\kappa}B$.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
RAW 264.7 대식세포에서 Gelidium amansii의 항염증 효과
동의생리병리학회지
2009 .06
-
Anti-inflammatory Effects of the Methanol Extract of Polytrichum Commune via NF-κB Inactivation in RAW 264.7 Macrophage Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2008 .01
-
장뇌산삼의 $NF-{\kappa}B$ 억제를 통한 RAW 264.7 세포에서의 항염증 효과
동의생리병리학회지
2007 .01
-
상엽(桑葉) 추출물의 LPS로 유도된 RAW 264.7 세포에서의 항염증 효과
대한본초학회지(본초분과학회지)
2012 .01
-
폐 상피세포에서 NF-${\kappa}B/I{\kappa}B$ 경로에 의한 염증매개 사이토카인의 발현
Tuberculosis and Respiratory Diseases
2000 .01
-
대식세포주에서 인슐린이 $I{\kappa}B/NF-{\kappa}B$ 경로 활성화에 미치는 영향
Tuberculosis and Respiratory Diseases
2010 .01
-
Nuclear Factor kappa B 억제를 통한 인진추출물의 inducible Nitric Oxide synthase 및 Cytokine 억제효과
대한한의학방제학회지
2009 .01
-
A Methanol Extract of Adansonia digitata L. Leaves Inhibits Pro-Inflammatory iNOS Possibly via the Inhibition of NF-κB Activation
Biomolecules & Therapeutics(구 응용약물학회지)
2013 .01
-
Anti-inflammatory Activity of the Methanol Extract from the Stem of Coriandrum Sativum in RAW 264.7 Cells
대한본초학회지(본초분과학회지)
2018 .01
-
Anti-Inflammatory Constituents Isolated from Clerodendron trichotomum Tunberg Leaves (CTL) Inhibits Pro-inflammatory Gene Expression in LPS-stimulated RAW 264.7 Macrophages by Suppressing NF-${\kappa}$B Activation
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
백서의 급성폐손상에서 surfactant의 항염증작용과 호중구의 NK-${\kappa}B$ 활성과의 관계
Tuberculosis and Respiratory Diseases
2002 .01
-
Role of Salvia miltiorrhiza for Modulation of Th2-derived Cytokines in the Resolution of Inflammation
Immune Network
2011 .10
-
우무가사리(Gelidium amansii)의 구충성분에 대하여(제 1 보)
약학회지
1962 .01
-
三七花의 대식세포로부터 LPS에 의해 유도되는 nitric oxide와 전염증성 사이토카인의 생성 억제효과
대한한의학회지
2009 .01
-
Anti-inflammatory Effects of Ethanol Extract of Korean Medicinal Plants at Hwaak Mountain in LPS-induced RAW 264.7 Macrophages
대한본초학회지(본초분과학회지)
2017 .01
-
스테로이드의 투여가 말초혈액 단핵구에서 IkB/NF-κB경로에 미치는 영향
Tuberculosis and Respiratory Diseases
2003 .01
-
Inhibitory Effect of Citral on NO Production by Suppression of iNOS Expression and $NF-{\kappa}B$ Activation in RAW264.7 Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
Anti-Inflammatory Effects of Hexane Fraction from White Rose Flower Extracts via Inhibition of Inflammatory Repertoires
Biomolecules & Therapeutics(구 응용약물학회지)
2011 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0