지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background : Peripheral nerve injuries are a commonly encountered clinical problem and often result in a chronic pain and severe functional deficits.
Objective : The aim of this study was to evaluate the effects of Gentianae Macrophyllae Radix (G. M. Radix) on the pain control and the recovery of the locomotor function that results from the sciatic crushed nerve injury in rats.
Method : Using rats, we crushed their sciatic nerve, and then orally administered the aqueous extract of G. M. Radix. The effects of G. M. Radix on the recovery locomotor function were investigated by walking track analysis. The effects of G. M. Radix on pain control were investigated by brain-derived neurotrophic factor (BDNF) expression in the sciatic nerve, and c-Fos expression in the paraventricular nucleus (PVN) of the hypothalamus and in the ventrolateral periaqueductal gray (vlPAG).
Result : G. M. RADIX facilitates motor function from the locomotor deficit, and thereby increased BDNF expression and suppressed painful stimuli in the PVN and vlPAG after sciatic crushed nerve injury.
Conclusion : It is suggested that G. M. Radix might aid recovery locomotor function and control pain after sciatic crushed nerve injury. Further studies on identifying specific the component in G.M. Radix associated with enhanced neural activity in the peripheral nerve injury may be helpful to develop therapeutic strategies for the treatment of peripheral nerve injury.
Objective : The aim of this study was to evaluate the effects of Gentianae Macrophyllae Radix (G. M. Radix) on the pain control and the recovery of the locomotor function that results from the sciatic crushed nerve injury in rats.
Method : Using rats, we crushed their sciatic nerve, and then orally administered the aqueous extract of G. M. Radix. The effects of G. M. Radix on the recovery locomotor function were investigated by walking track analysis. The effects of G. M. Radix on pain control were investigated by brain-derived neurotrophic factor (BDNF) expression in the sciatic nerve, and c-Fos expression in the paraventricular nucleus (PVN) of the hypothalamus and in the ventrolateral periaqueductal gray (vlPAG).
Result : G. M. RADIX facilitates motor function from the locomotor deficit, and thereby increased BDNF expression and suppressed painful stimuli in the PVN and vlPAG after sciatic crushed nerve injury.
Conclusion : It is suggested that G. M. Radix might aid recovery locomotor function and control pain after sciatic crushed nerve injury. Further studies on identifying specific the component in G.M. Radix associated with enhanced neural activity in the peripheral nerve injury may be helpful to develop therapeutic strategies for the treatment of peripheral nerve injury.
목차
Introduction
Materials and methods
Results
Discussion
Conclusion
References
참고문헌 (36)
참고문헌 신청
1. [학술지(정기간행물)] - Irving GA / 2005 / Contemporary assessment and management of neuropathic pain / Neurology 64 : S21 ~ S27
2. [학술지(정기간행물)] - Bervar M / 2000 / Video analysis of standing--an alternative footprint analysis to assess functional loss following injury to the rat sciatic nerve / Journal of Neuroscience Methods 102 : 109 ~ 116
3. [학술지(정기간행물)] - de Medinaceli L / 1982 / An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks / Experimental Neurology 77 : 634 ~ 643
4. [학술지(정기간행물)] - Bain JR / 1989 / Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat / Plastic and Reconstructive Surgery 83 : 129 ~ 138
5. [학술지(정기간행물)] - Huang EJ / 2001 / Neurotrophins: Roles in neuronal development and function / Annual Review of Neuroscience 24 : 677 ~ 736
2. [학술지(정기간행물)] - Bervar M / 2000 / Video analysis of standing--an alternative footprint analysis to assess functional loss following injury to the rat sciatic nerve / Journal of Neuroscience Methods 102 : 109 ~ 116
3. [학술지(정기간행물)] - de Medinaceli L / 1982 / An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks / Experimental Neurology 77 : 634 ~ 643
4. [학술지(정기간행물)] - Bain JR / 1989 / Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat / Plastic and Reconstructive Surgery 83 : 129 ~ 138
5. [학술지(정기간행물)] - Huang EJ / 2001 / Neurotrophins: Roles in neuronal development and function / Annual Review of Neuroscience 24 : 677 ~ 736
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of Acupuncture at GB30, GB34, and BL40 on Functional Recovery after Sciatic Crushed Nerve Injury in Rats
대한한의학회지
2010 .05
-
Effects of amygdalin on the functional recovery and c-Fos expression in the ventrolateral periaqueductal gray region after sciatic crushed nerve injury in rats
Oriental pharmacy and experimental medicine
2008 .01
-
Dexmedetomidine Improves Locomotor Function and Alleviates Thermal Hyperalgesia Following Sciatic Nerve Crush Injury in Rats
International Neurourology Journal
2020 .01
-
Effects of Bee Venom and Sweet Bee Venom Acupuncture on Functional Recovery and c-Fos Expression in the Brain after Sciatic Crushed Nerve Injury in Rats
대한한의학회지
2010 .05
-
The Effects of Aqueous Extracts of Aconiti ciliare tuber on Functional Recovery after Sciatic Crushed Nerve Injury in Rats
대한한의학회지
2009 .05
-
초음파 치료가 좌골신경 압좌 손상된 흰쥐의 c-Fos 발현에 미치는 영향
대한물리치료사학회지
2007 .01
-
좌골신경 손상에 대한 한약물 치료효과에 대한 실험논문 분석 - 국내외 한의계 연구를 중심으로 -
한방재활의학과학회지
2016 .01
-
좌골신경 손상된 랫드에서 초음파 조사에 의한 좌골신경 기능지수 향상효과
Laboratory Animal Research
2004 .06
-
말초신경 손상의 복원방법에 대한 비교연구
대한정형외과학회지
1993 .08
-
초음파 조사에 의한 좌골신경 손상된 랫드 요척수부에서의 c-fos 발현양상
Laboratory Animal Research
2004 .06
-
Effects of Herbal Bath on Functional Recovery and c-Fos Expression in the Ventrolateral Periaqueductal Gray Region of the Brain after Sciatic Crushed-Nerve Injury in Rats
대한한의학회지
2006 .12
-
흰쥐 좌골신경 압좌손상 후 척수분절의 저강도 레이저 조사가 운동기능 회복에 미치는 영향
대한물리치료학회지(JKPT)
2001 .01
-
Effects of Low Power Laser on Pain Response and Axonal Regeneration in Rat Models with Sciatic Nerve Crush Injury
Journal of international academy of physical therapy research
2012 .01
-
방사선치료 후 발생한 좌골신경염에 대한 초음파 유도하 좌골신경차단-증례보고-
The Korean Journal of Pain
2009 .01
-
홍삼사포닌이 좌골신경 재생에 미치는 영향
Journal of Ginseng Research
2003 .09
-
좌골신경가동화기법이 만성 요통 환자의 통증과 슬관절 신전근력에 미치는 영향
한국전문물리치료학회지
2010 .01
-
저출력 레이저 치료가 흰쥐 좌골신경의 재생에 미치는 효과
Annals of Rehabilitation Medicine
2004 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-519-000263637