지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objective : The aim of this study was to evaluate the effects of Aconiti ciliare tuber on the descending pain and the recovery of locomotor function that results from sciatic crushed nerve injury in rats.
Method : In order to assess the effects of the aqueous extract of Aconiti ciliare tuber on the recovery rate of locomotor function, we investigated the walking track analysis, and for the effects on the pain control we investigated brain-derived neurotrophic factor (BDNF) and inducible nitric oxide synthase (iNOS) expression in the sciatic nerve and on the expressions of c-Fos in the ventrolateral periaqueductal gray (vlPAG) region resulting from the sciatic crushed nerve injury in rats.
Result : Treatment with Aconiti ciliare tuber significantly enhanced the SFIvalue, enhanced BDNF expression, decreased iNOS expression, and suppressed c-Fos expression. The present results showed that Aconiti ciliare tuber facilitated functional recovery following sciatic crushed nerve injury in rats. The recovery mechanisms of SFI by Aconiti ciliare tuber might be ascribed to the increase of BDNF expression for nerve regeneration and reinnervation and to the suppression of iNOS expression for inhibiting nerve inflammation.
Conclusion : In this process it has been shown that Aconiti ciliare tuber can be used for pain control and functional recovery from peripheral nerve injury.
Method : In order to assess the effects of the aqueous extract of Aconiti ciliare tuber on the recovery rate of locomotor function, we investigated the walking track analysis, and for the effects on the pain control we investigated brain-derived neurotrophic factor (BDNF) and inducible nitric oxide synthase (iNOS) expression in the sciatic nerve and on the expressions of c-Fos in the ventrolateral periaqueductal gray (vlPAG) region resulting from the sciatic crushed nerve injury in rats.
Result : Treatment with Aconiti ciliare tuber significantly enhanced the SFIvalue, enhanced BDNF expression, decreased iNOS expression, and suppressed c-Fos expression. The present results showed that Aconiti ciliare tuber facilitated functional recovery following sciatic crushed nerve injury in rats. The recovery mechanisms of SFI by Aconiti ciliare tuber might be ascribed to the increase of BDNF expression for nerve regeneration and reinnervation and to the suppression of iNOS expression for inhibiting nerve inflammation.
Conclusion : In this process it has been shown that Aconiti ciliare tuber can be used for pain control and functional recovery from peripheral nerve injury.
목차
Introduction
Materials and methods
Results
Discussion
Conclusion
References
참고문헌 (51)
참고문헌 신청
1. [학술지(정기간행물)] - Bennett GJ / 1998 / A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man / Pain 33 : 87 ~ 107
2. [학술지(정기간행물)] - Meller ST / 1992 / Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat / Neuroscience 50 : 7 ~ 10
3. [학술지(정기간행물)] - Narita M / 2003 / Change in the expression of c-fos in the rat brain following sciatic nerve ligation / Neurosci Lett 352 : 231 ~ 233
4. [학술지(정기간행물)] - Bervar M / 2000 / Video analysis of standing-an alternative footprint analysis to assess functional loss following injury to the rat sciatic nerve / J Neurosci Methods 102 : 109 ~ 116
5. [학술지(정기간행물)] - De Medinaceli L / 1982 / An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks / Exp Neurol 77 : 634 ~ 643
2. [학술지(정기간행물)] - Meller ST / 1992 / Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat / Neuroscience 50 : 7 ~ 10
3. [학술지(정기간행물)] - Narita M / 2003 / Change in the expression of c-fos in the rat brain following sciatic nerve ligation / Neurosci Lett 352 : 231 ~ 233
4. [학술지(정기간행물)] - Bervar M / 2000 / Video analysis of standing-an alternative footprint analysis to assess functional loss following injury to the rat sciatic nerve / J Neurosci Methods 102 : 109 ~ 116
5. [학술지(정기간행물)] - De Medinaceli L / 1982 / An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks / Exp Neurol 77 : 634 ~ 643
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UCI(KEPA) : I410-ECN-0101-2014-519-000263642