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논문 기본 정보

자료유형
학술저널
저자정보
Yoonjung Cho (Yonsei University) Jaewon Lim (Yonsei University) Dong Hyun Lee (Yonsei University) Byung Chul Jung (Yonsei University) Min Ho Lee (Yonsei University) Dongju Jung (Kyoto University) Yoon Suk Kim (Yonsei University) Tae Ue Kim (Yonsei University) Ki-Jong Rhee (Yonsei University)
저널정보
대한의생명과학회 대한의생명과학회지 대한의생명과학회지 제19권 제1호
발행연도
2013.3
수록면
9 - 16 (8page)

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초록· 키워드

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Elevated blood triglyceride (TG) levels correlate with development of atherosclerosis suggesting that TG may promote the development of this disease. During atherosclerosis, TG is taken up by tissue macrophages which result in dramatic changes in various secreted factors. One such factor is the family of matrix metalloproteases (MMP) which are involved in tissue remodeling during both physiological and pathological processes. In this study, we examined the MMP expression profile in PMA-differentiated THP-1 macrophages treated with TG. We found that TG-treated THP-1 macrophages showed decreased expression of MMP-3, MMP-7, MMP-8 and MMP-9 in a time- and dose-dependent manner. In contrast, expression of MMP-1, MMP-2, and MMP-10 remained relatively unchanged after TG treatment. In addition, we found that expression of select MMPs was affected by various inhibitors of signaling pathways. In particular, expression of MMP-3 was slightly recovered by cRAF and PLC signaling pathway inhibitors. These data suggests a possible role of MMPs in macrophages during TG-induced atherosclerosis.

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INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2014-520-003115711