지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Elevated blood triglyceride (TG) levels correlate with development of atherosclerosis suggesting that TG may promote the development of this disease. During atherosclerosis, TG is taken up by tissue macrophages which result in dramatic changes in various secreted factors. One such factor is the family of matrix metalloproteases (MMP) which are involved in tissue remodeling during both physiological and pathological processes. In this study, we examined the MMP expression profile in PMA-differentiated THP-1 macrophages treated with TG. We found that TG-treated THP-1 macrophages showed decreased expression of MMP-3, MMP-7, MMP-8 and MMP-9 in a time- and dose-dependent manner. In contrast, expression of MMP-1, MMP-2, and MMP-10 remained relatively unchanged after TG treatment. In addition, we found that expression of select MMPs was affected by various inhibitors of signaling pathways. In particular, expression of MMP-3 was slightly recovered by cRAF and PLC signaling pathway inhibitors. These data suggests a possible role of MMPs in macrophages during TG-induced atherosclerosis.
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INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
Adams LD / 2006 / Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap / Arterioscler Thromb Vasc Biol 26:319~325
Amalinei C / 2010 / Matrix metalloproteinases involvement in pathologic conditions / Rom J Morphol Embryol 51:215~228
Amorino GP / 1998 / Interactions of monocytic cells with human endothelial cells stimulate monocytic metalloproteinase production / Am J Pathol 152:199~207
Armstrong C / 2007 / Polymorphisms in MMP family and TIMP genes and carotid artery intima-media thickness / Stroke 38:2895~2899
Bar-Or A / 2003 / Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis / Brain 126:2738~2749
Amalinei C / 2010 / Matrix metalloproteinases involvement in pathologic conditions / Rom J Morphol Embryol 51:215~228
Amorino GP / 1998 / Interactions of monocytic cells with human endothelial cells stimulate monocytic metalloproteinase production / Am J Pathol 152:199~207
Armstrong C / 2007 / Polymorphisms in MMP family and TIMP genes and carotid artery intima-media thickness / Stroke 38:2895~2899
Bar-Or A / 2003 / Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis / Brain 126:2738~2749
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UCI(KEPA) : I410-ECN-0101-2014-520-003115711