지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The aim of this study was to evaluate the effect of exercise-based cardiac rehabilitation on pro- and anti-inflammatory markers in patients with acute coronary syndrome (ACS). ACS patients who underwent percutaneous coronary intervention (PCI) and took medicine during phase II of rehabilitation were recruited for study. Subjects were divided into two groups; exercise group (EX, n=21) and a non-exercise group (non-EX, n=13). Supervised exercise program in hospital consisted of treadmill and bicycle exercise was performed three times per week for 6 weeks. Patients of EX received individual counseling, including knowledge of heart disease, risk factor modification, and physical training. Cardiopulmonary fitness, body composition, and biochemical blood factors were analyzed before and after experiment. There was no significant difference in serum levels of hs-CRP and TGF-β1 between groups, and between time intervals. But there was a significant decrease in serum levels of IL-18 (P<.001). And there was a significant increase in ratio of IL-18 to IL-10 (P<.01) and serum levels of IL-10 (P<.001). After cardiac rehabilitation, there was significant increase in exercise duration (P<.001), maximal oxygen uptake (VO<SUB>2peak</SUB>; P<.001) and decrease in submaximal rate-pressure product (sRPP; P<.05) in EX. In conclusion, exercise-based cardiac rehabilitation during phase II in patients with ACS after PCI decreased serum IL-18 (pro-inflammatory) content and ratio of IL-18 to IL-10 in serum (highly related with disease recurrence), and increased serum IL-10 (anti-inflammatory) content. In addition, it led to improved cardiopulmonary fitness.
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REFERENCES
참고문헌 (46)
참고문헌 신청
AACVPR (American Association of Cardiovascular and Pulmonary Rehabilitation) / 1995 / Guidelines for cardiac rehabilitation programs / Human Kinetics
Ades PA / 2001 / Transforming exercise-based cardiac rehabilitation programs into secondary prevention centers: a national imperative / J Cardiopulm Rehabil 21:263~272
Alam SE / 2004 / Cytokine imbalance in acute coronary syndrome / Curr Opin Pharmacol 4:166~170
Andreotti F / 2002 / Inflammatory gene polymorphisms and ischemic heart disease: review of population association studies / Heart 87:107~112
Balady GJ / 2000 / Core components of cardiac rehabilitation/secondary prevention programs: A statement for healthcare professionals from the American Heart Association and the American Association of Cardiovascular and Pulmonary Rehabilitation Writing Group / Circulation 102:1069~1073
Ades PA / 2001 / Transforming exercise-based cardiac rehabilitation programs into secondary prevention centers: a national imperative / J Cardiopulm Rehabil 21:263~272
Alam SE / 2004 / Cytokine imbalance in acute coronary syndrome / Curr Opin Pharmacol 4:166~170
Andreotti F / 2002 / Inflammatory gene polymorphisms and ischemic heart disease: review of population association studies / Heart 87:107~112
Balady GJ / 2000 / Core components of cardiac rehabilitation/secondary prevention programs: A statement for healthcare professionals from the American Heart Association and the American Association of Cardiovascular and Pulmonary Rehabilitation Writing Group / Circulation 102:1069~1073
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UCI(KEPA) : I410-ECN-0101-2014-500-003115788