지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.18 No.2
- 발행연도
- 2013.6
- 수록면
- 111 - 116 (6page)
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초록· 키워드
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Chrysanthemum indicum is widely used to treat immune-related and infectious disorders in East Asia. C. indicum flower oil contains 1,8-cineole, germacrene D, camphor, α-cadinol, camphene, pinocarvone, β-caryophyllene, 3-cyclohexen- -ol, and γ-curcumene. We evaluated the safety of C. indicum flower oil by conducting acute oral toxicity, bone marrow micronucleus, and bacterial reverse mutation tests. Mortality, clinical signs and gross findings of mice were measured for 15 days after the oral single gavage administration of C. indicum flower oil. There were no mortality and clinical signs of toxicity at 2,000 ㎎/㎏ body weight/day of C. indicum flower oil throughout the 15 day period. Micronucleated erythrocyte cell counts for all treated groups were not significantly different between test and control groups. Levels of 15.63∼500 μg C. indicum flower oil/plate did not induce mutagenicity in S. Typhimurium and E. coli, with or without the introduction of a metabolic activation system. These results indicate that ingesting C. indicum flower oil produces no acute oral toxicity, bone marrow micronucleus, and bacterial reverse mutation.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESTULS AND DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Yu DO / 1992 / Application of 2D NMR techniques in the structure determination of chrysanthetriol / Acta Pharmaceutica Sinica 27 : 191 ~ 196
2. [학술지(정기간행물)] - Matsuda H / 2002 / Medicinal flowers. VI. absolute stereostructures of two new flavanone glycosides and a phenylbutanoid glycoside from the flowers of Chrysanthemum indicum L. : their inhibitory activities for rat lens aldose reductase / Chem Pharm Bull 50 : 972 ~ 975
3. [학술지(정기간행물)] - Cheng W / 2005 / Anti-inflammatory and immunomodulatory activities of the extracts from the inflorescence of Chrysanthemum indicum Linne / J Ethnopharmacol 101 : 334 ~ 337
4. [학술지(정기간행물)] - Kim HG / 1995 / Antioxidative activity and physiological activity of some Korean medicinal plants / Korean J Food Sci Technol 27 : 80 ~ 85
5. [학술지(정기간행물)] - Je-Hyuk Lee / 2009 / Anti-inflammatory Activities of Chopi (Zanthoxylum piperitum A.P. DC) Essential Oil: Suppression of the Inducible Nitric Oxide Synthase and Cellular Adhesion / Food Science and Biotechnology 18 (6) : 1371 ~ 1378
2. [학술지(정기간행물)] - Matsuda H / 2002 / Medicinal flowers. VI. absolute stereostructures of two new flavanone glycosides and a phenylbutanoid glycoside from the flowers of Chrysanthemum indicum L. : their inhibitory activities for rat lens aldose reductase / Chem Pharm Bull 50 : 972 ~ 975
3. [학술지(정기간행물)] - Cheng W / 2005 / Anti-inflammatory and immunomodulatory activities of the extracts from the inflorescence of Chrysanthemum indicum Linne / J Ethnopharmacol 101 : 334 ~ 337
4. [학술지(정기간행물)] - Kim HG / 1995 / Antioxidative activity and physiological activity of some Korean medicinal plants / Korean J Food Sci Technol 27 : 80 ~ 85
5. [학술지(정기간행물)] - Je-Hyuk Lee / 2009 / Anti-inflammatory Activities of Chopi (Zanthoxylum piperitum A.P. DC) Essential Oil: Suppression of the Inducible Nitric Oxide Synthase and Cellular Adhesion / Food Science and Biotechnology 18 (6) : 1371 ~ 1378
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UCI(KEPA) : I410-ECN-0101-2014-510-003288046