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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 118 - 123 (6page)
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Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that mediates the inflammatory response and immune functions, and modulates the proliferation, differentiation and cell death of cancer cells. The differential functions of TNF-α in various human cells due to the formation of different stimulating pathway upon the binding of TNF-α to its receptors. In the present study, we examined the different effects of TNF-α on the survival and apoptosis between normal granulocytes and human myeloid leukemia HL-60 cells. Although TNF-α did not affect on the constitutive apoptosis of granulocytes, TNF-α strongly induced the apoptosis of HL-60 cells in a dose- and a time-dependent manner. TNF-α-induced apoptosis was occurred via the activation of caspase 8, caspase 9 and caspase 3/7 and the induction of ROS production in HL-60 cells. Also, BAY-11-7085, a NF-κB inhibitor, blocked the TNF-α-induced apoptosis in HL-60 cells. NF-κB may be involved in TNF-α-induced apoptotic signaling pathway in HL-60 cells. These results suggest that TNF-α activates apoptotic pathways and its process depends on cell type and many cellular factors. A better understanding of the differential effect of TNF-α on cell apoptosis and survival may provide important information that can be used to elucidate the specific inhibitory effect of TNF-α on the cancer dis.
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REFERENCES
참고문헌 (22)
참고문헌 신청
Baker SJ / 1998 / Modulation of life and death by the TNF receptor superfamily / Oncogene 17:3261~3270
Baud V / 2001 / Signal transduction by tumor necrosis factor and its relatives / Trends Cell Biol 11:372~377
Callard RE / 2005 / Immunology and mathematics: Crossing the divide / Immunology 115:21~33
유선미 / 2007 / Effects of Vanillic Acid on the Cell Viability and Melanogenesis in Cultured Human Skin Melanoma Cells Damaged by ROS-Induced Cytotoxicity / 대한의생명과학회지 13(4):349~354
Hayden MS / 2004 / Signaling to NF-kappaB pathway / Genes Dev 18:2195~2224
Baud V / 2001 / Signal transduction by tumor necrosis factor and its relatives / Trends Cell Biol 11:372~377
Callard RE / 2005 / Immunology and mathematics: Crossing the divide / Immunology 115:21~33
유선미 / 2007 / Effects of Vanillic Acid on the Cell Viability and Melanogenesis in Cultured Human Skin Melanoma Cells Damaged by ROS-Induced Cytotoxicity / 대한의생명과학회지 13(4):349~354
Hayden MS / 2004 / Signaling to NF-kappaB pathway / Genes Dev 18:2195~2224
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UCI(KEPA) : I410-ECN-0101-2014-500-003262928