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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 124 - 131 (8page)
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Genome-wide association studies (GWAS) have identified a number of common variants associated with serum liver enzyme homeostasis in population. In the previous study, single nucleotide polymorphisms (SNPs) in several genes have been reported to be associated with serum liver enzyme levels in European population. We aimed to confirm whether the genetic variation of SMAD2 (SMAD family member 2) gene influence the serum liver enzyme levels in Korean population. We genotyped variants in or near SMAD2 in a population-based sample including 994 unrelated Korean adult. Here, we performed association analysis to elucidate the possible relations of genetic polymorphisms in SMAD2 gene with serum liver enzyme levels. By examining genotype data of a total of 944 subjects in 5 hospital health promotion center, we discovered the SMAD2 gene polymorphisms are associated with serum liver enzyme levels. The common and highest significant polymorphism was rs17736760 (β=3.51, P=5.31E-07) with glutamic oxaloacetic transferase (GOT), rs17736760 (β=5.99, P=1.25E-05) with glutamic pyruvate transaminase (GPT), and rs17736760 (β=15.68, P=9.93E-07) with gamma glutamyl transferase (GGT) in all group. Furthermore, the SNP rs17736760 was consistently associated with GOT (β=5.25, P=1.72E-06), GPT (β=9.97, P=1.16E-05), GGT (β=26.13, P=3.43E-06) in men group. Consequently, we found statistically significant SNP in SMAD2 gene that are associated with serum levels of GOT, GPT, and GGT. In addition, these results suggest that the individuals with the minor alleles of the SNP in the SMAD2 gene may be more elevated serum liver enzyme levels in the Korean population.
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REFERENCES
참고문헌 (13)
참고문헌 신청
Bathum L / 2001 / Evidence for a substantial genetic influence on biochemical liver function tests: results from a populationbased Danish twin study / Clin Chem 47:81~87
Forlani G / 2008 / Prevalence of elevated liver enzymes in Type 2 diabetes mellitus and its association with the metabolic syndrome / J Endocrinol Invest 31:146~152
French D / 2009 / Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia / Blood 113:4512~4520
Ju W / 2006 / Deletion of SMAD2 in mouse liver reveals novel functions in hepatocyte growth and differentiation / Mol Cell Biol 26:654~667
Kazemi-Shirazi L / 2007 / Gamma glutamyltransferase and long-term survival: is it just the liver? / Clin Chem 53:940~946
Forlani G / 2008 / Prevalence of elevated liver enzymes in Type 2 diabetes mellitus and its association with the metabolic syndrome / J Endocrinol Invest 31:146~152
French D / 2009 / Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia / Blood 113:4512~4520
Ju W / 2006 / Deletion of SMAD2 in mouse liver reveals novel functions in hepatocyte growth and differentiation / Mol Cell Biol 26:654~667
Kazemi-Shirazi L / 2007 / Gamma glutamyltransferase and long-term survival: is it just the liver? / Clin Chem 53:940~946
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UCI(KEPA) : I410-ECN-0101-2014-500-003262933