지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 147 - 152 (6page)
이용수
초록· 키워드
오류제보하기
17-β-hydroxysteroid dehydrogenase type 1 (17β-HSD type 1) mediates the reaction of 17β-estradiol (E2) production from estrone (E1). Inhibitory effects of curcuminoids on 17β-HSD type 1 activity were investigated to find a lead compound for treating estrogen-dependent diseases including breast cancer. Among curcuminoids, demethoxycurcumin showed potent inhibitory effect (IC50 = 2.7 μM) on mouse 17β-HSD type 1. Curcuminoids also displayed their inhibitory effects on the production of 17α-estradiol which is a carcinogenic metabolite produced by the enzyme. Bisdemethoxycurcumin (IC?? = 1.3 μM) showed potent inhibitory effect on the 17α-estradiol production by chicken 17β-HSD type 1. Curcuminoids did not inhibit ERE transcriptional activity with and without E2. Taken together, curcuminoids can be used for treating and preventing E2-dependent diseases via inhibition on 17β-HSD type 1 activity.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Aka JA / 2010 / 17betahydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production / Mol Endocrinol 24:832~845
Aka JA / 2009 / Reductive 17beta-hydroxysteroid dehydrogenases in the sulfatase pathway: critical in the cell proliferation of breast cancer / Mol Cell Endocrinol 301:183~191
Anand P / 2007 / Bioavailability of curcumin: problems and promises / Mol Pharmaceutics 4:807~818
Hajek RA / 1997 / During development, 17alpha-estradiol is a potent estrogen and carcinogen / Environ Health Perspect 105(Suppl. 3):577~581
Hu GX / 2010 / Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3 / Bioorg Med Chem Lett 20:2549~2951
Aka JA / 2009 / Reductive 17beta-hydroxysteroid dehydrogenases in the sulfatase pathway: critical in the cell proliferation of breast cancer / Mol Cell Endocrinol 301:183~191
Anand P / 2007 / Bioavailability of curcumin: problems and promises / Mol Pharmaceutics 4:807~818
Hajek RA / 1997 / During development, 17alpha-estradiol is a potent estrogen and carcinogen / Environ Health Perspect 105(Suppl. 3):577~581
Hu GX / 2010 / Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3 / Bioorg Med Chem Lett 20:2549~2951
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Septicemia Caused by Leuconostoc lactis with Intrinsic Resistance to Vancomycin in a Patient with Biliary Stent
Kyeong Seob Shin
,
Kyudong Han
,
Seung Bok Hong
대한의생명과학회지
2013
.09
Comparison of Molecular Characteristics of Extended Spectrum β-lactamase Producing Escherichia coli Strains Isolated from Patients with Urinary Tract Infections between 2 Time Periods of 1989 and 2010 at Gangwon Province in Korea
Min Pa
,
k
,
Soon Deok Pa
외 10명
대한의생명과학회지
2013
.09
Isoliquiritigenin Inhibits Ovalbumin-induced Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression
Se Jin Lim
,
Hyung-Sun Youn
대한의생명과학회지
2013
.09
Direct Interaction Between Akt1 and Gcn5 and its Plausible Function on Hox Gene Expression in Mouse Embryonic Fibroblast Cells
Ji Hoon Oh
,
You
,
a Lee
외 2명
대한의생명과학회지
2013
.09
Endothelial Cells Isolated from the Bovine Corpus Luteum Synthesize Prostaglandin F2α Receptor
Sun‐Yeong Gwon
,
Ki‐Jong Rhee
,
Seunghyung Lee
대한의생명과학회지
2013
.09
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-500-003262968