지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 63 - 69 (7page)
이용수
초록· 키워드
오류제보하기
Ferulic acid, a component of the plants Angelica sinensis (Oliv.) Diels and Ligusticum chuanxiong Hort, exerts a neuroprotective effect by regulating various signaling pathways. This study showed that ferulic acid treatment prevents the injury-induced increase of collapsin response mediator protein 2 (CRMP-2) in focal cerebral ischemia. Glycogen synthase kinase-3β (GSK-3β) regulates CRMP-2 function through phosphorylation of CRMP-2. Moreover, the pro-apoptotic activity of GSK-3β is inactivated by phosphorylation by Akt. This study investigated whether ferulic acid modulates the expression of CRMP-2 and its upstream targets, Akt and GSK-3β, in focal cerebral ischemia. Male rats were treated immediately with ferulic acid (100 mg/kg, i.v.) or vehicle after middle cerebral artery occlusion (MCAO), and then cerebral cortices were collected 24 hr after MCAO. MCAO resulted in decreased levels of phospho-Akt and phospho-GSK-3β, while ferulic acid treatment prevented the decrease in the levels of these proteins. Moreover, phospho-CRMP-2 and CRMP-2 levels increased during MCAO, whereas ferulic acid attenuated these injury-induced increases. These results demonstrate that ferulic acid regulates the Akt/GSK-3β/CRMP-2 signaling pathway in focal cerebral ischemic injury, thereby protecting against brain injury.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (26)
참고문헌 신청
Sultana R / 2005 / Ferulic acid ethyl ester protects neurons against amyloid beta-peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity / J Neurochem 92(4):749~758
Srinivasan M / 2006 / Influence of ferulic acid on gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes / Toxicology 228(2):249~258
Srinivasan M / 2007 / Ferulic Acid: therapeutic potential through its antioxidant property. Ferulic Acid: therapeutic potential through its antioxidant property / J Clin Biochem Nutr 40(2):92~100
Kawabata K / 2000 / Modifying effects of ferulic acid on azoxymethane-induced colon carcinogenesis in F344 rats / Cancer Lett 157(1):15~21
Ohnishi M / 2004 / Antioxidant activity and hypoglycemic effect of ferulic acid in STZ-induced diabetic mice and KK-Ay mice / Biofactors 21(1):315~319
Srinivasan M / 2006 / Influence of ferulic acid on gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes / Toxicology 228(2):249~258
Srinivasan M / 2007 / Ferulic Acid: therapeutic potential through its antioxidant property. Ferulic Acid: therapeutic potential through its antioxidant property / J Clin Biochem Nutr 40(2):92~100
Kawabata K / 2000 / Modifying effects of ferulic acid on azoxymethane-induced colon carcinogenesis in F344 rats / Cancer Lett 157(1):15~21
Ohnishi M / 2004 / Antioxidant activity and hypoglycemic effect of ferulic acid in STZ-induced diabetic mice and KK-Ay mice / Biofactors 21(1):315~319
이 논문의 저자 정보
이 논문과 함께 이용한 논문
미나리 분말을 첨가한 청국장의 발효 및 품질특성
이신호
,
김진학
한국식품영양과학회지
2013
.07
일제강점기 ｢돌이와 두꺼비｣동화에 나타난 개작 양상 연구
김경희
국학연구
2013
.06
베어링 배열방식이 고속 스핀들의 동특성에 미치는 영향
홍성욱
,
최춘석
,
이찬홍
Journal of the Korean Society for Precision Engineering
2013
.08
왕복동식 압축기의 저널 베어링 오일 패스 설계를 위한 연구
조인성
,
정재연
Journal of the Korean Society for Precision Engineering
2013
.08
Effect of Surface Treatment on Fatigue Strength of SCM440H
Hyunho Yeom
,
Moon Gu Lee
,
Choon Man Lee
외 1명
Journal of the Korean Society for Precision Engineering
2013
.08
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-500-003193920