지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 491 - 504 (14page)
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초록· 키워드
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This review article provides an overview of the evolution of diphtheria vaccine, its value and its future. Diphtheria is an infectious illness caused by diphtheria toxin produced by pathogenic strains of Corynebacterium diphtheriae. It is characterized by a sore throat with membrane formation due to local tissue necrosis, which can lead to fatal airway obstruction; neural and cardiac damage are other common complications. Diphtheria vaccine was first brought to market in the 1920s, following the discovery that diphtheria toxin can be detoxified using formalin. However, conventional formalin-inactivated toxoid vaccines have some fundamental limitations. Innovative technologies and approaches with the potential to overcome these limitations are discussed in this paper. These include genetic inactivation of diphtheria toxoid, innovative vaccine delivery systems, new adjuvants (both TLRindependent and TLR-dependent adjuvants), and heat- and freeze-stable agents, as well as novel platforms for producing improved conventional vaccine, DNA vaccine, transcutaneous (microneedle-mediated) vaccine, oral vaccine and edible vaccine expressed in transgenic plants. These innovations target improvements in vaccine quality (efficacy, safety, stability and consistency), ease of use and/or thermal stability. Their successful development and use should help to increase global diphtheria vaccine coverage.
목차
Abstract
1. Introduction
2. General description of Corynebacterium diphtheriae
3. How Corynebacterium diphtheriae causes illness
4. Conventional technologies for formalin-detoxifiedvaccine
5. Genetically detoxified vaccine
6. Cutting-edge technologies for innovative vaccines
7. Perspectives
References
참고문헌 (132)
참고문헌 신청
1. [학술지(정기간행물)] - Akama, K / 1971 / Reversion of toxicity of diphtheria toxoid / Japanese Journal of Medical Science & Biology 24 : 183 ~ 187
2. [학술지(정기간행물)] - Amorij, J. P / 2007 / Towards an oral influenza vaccine: comparison between intragastric and intracolonicdelivery of influenza subunit vaccine in a murine model / Vaccine 26 : 67 ~ 76
3. [학술대회논문] - Anderson, D. G / 2004 / A polymer library approach to suicide gene therapy for cancer / Proceedings of the National Academy of Sciences of the United States of America : 16028 ~ 16033
4. [학술지(정기간행물)] - Anderson, P / 2003 / Non-interference between two protein carriers when used with the same polysaccharide for pneumococcal conjugate vaccines in 2-year-old children / Vaccine 21 : 1554 ~ 1559
5. [학술지(정기간행물)] - Antoni, G. / 1983 / Purification of diphtheria toxin by chromatography on cibacron blue-sepharose / Experientia 39 : 885 ~ 886
2. [학술지(정기간행물)] - Amorij, J. P / 2007 / Towards an oral influenza vaccine: comparison between intragastric and intracolonicdelivery of influenza subunit vaccine in a murine model / Vaccine 26 : 67 ~ 76
3. [학술대회논문] - Anderson, D. G / 2004 / A polymer library approach to suicide gene therapy for cancer / Proceedings of the National Academy of Sciences of the United States of America : 16028 ~ 16033
4. [학술지(정기간행물)] - Anderson, P / 2003 / Non-interference between two protein carriers when used with the same polysaccharide for pneumococcal conjugate vaccines in 2-year-old children / Vaccine 21 : 1554 ~ 1559
5. [학술지(정기간행물)] - Antoni, G. / 1983 / Purification of diphtheria toxin by chromatography on cibacron blue-sepharose / Experientia 39 : 885 ~ 886
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UCI(KEPA) : I410-ECN-0101-2014-400-002405342