지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.10
- 수록면
- 451 - 456 (6page)
이용수
초록· 키워드
오류제보하기
Compound K is a major metabolite of ginsenoside Rb1, which has various pharmacological activities in vivo and in vitro. However, previous studies have focused on the pharmacokinetics of a single metabolite or the parent compound and have not described the pharmacokinetics of both compounds in humans. To investigate the pharmacokinetics of ginsenoside Rb1 and compound K, we performed an open-label, single-oral dose pharmacokinetic study using Korean Red Ginseng extract. We enrolled 10 healthy Korean male volunteers in this study. Serial blood samples were collected during 36 h after Korean Red Ginseng extract administration to determine plasma concentrations of ginsenoside Rb1 and compound K. The mean maximum plasma concentration of compound K was 8.35±3.19 ng/mL, which was significantly higher than that of ginsenoside Rb1 (3.94±1.97 ng/mL). The half-life of compound K was 7 times shorter than that of ginsenoside Rb1. These results suggest that the pharmacokinetics, especially absorption, of compound K are not influenced by the pharmacokinetics of its parent compound, except the time to reach the maximum plasma concentration The delayed absorption of compound K support the evidence that the intestinal microflora play an important role in the transformation of ginsenoside Rb1 to compound K.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Christensen LP. / 2009 / Ginsenosides chemistry, biosynthesis, analysis, and potential health effects / Adv Food Nutr Res 55 : 1 ~ 99
2. [학술지(정기간행물)] - Kang KS / 2006 / Protective effect of sun ginseng against diabetic renal damage / Biol Pharm Bull 29 : 1678 ~ 1684
3. [학술지(정기간행물)] - Yun TK. / 2001 / Panax ginseng: a non-organ-specific cancer preventive? / Lancet Oncol 2 : 49 ~ 55
4. [학술지(정기간행물)] - Qi LW / 2010 / American ginseng: potential structure-function relationship in cancer chemoprevention / Biochem Pharmacol 80 : 947 ~ 954
5. [학술지(정기간행물)] - Attele AS / 1999 / Ginseng pharmacology: multiple constituents and multiple actions / Biochem Pharmacol 58 : 1685 ~ 1693
2. [학술지(정기간행물)] - Kang KS / 2006 / Protective effect of sun ginseng against diabetic renal damage / Biol Pharm Bull 29 : 1678 ~ 1684
3. [학술지(정기간행물)] - Yun TK. / 2001 / Panax ginseng: a non-organ-specific cancer preventive? / Lancet Oncol 2 : 49 ~ 55
4. [학술지(정기간행물)] - Qi LW / 2010 / American ginseng: potential structure-function relationship in cancer chemoprevention / Biochem Pharmacol 80 : 947 ~ 954
5. [학술지(정기간행물)] - Attele AS / 1999 / Ginseng pharmacology: multiple constituents and multiple actions / Biochem Pharmacol 58 : 1685 ~ 1693
이 논문의 저자 정보
이 논문과 함께 이용한 논문
고부가가치 산업화를 위한 인삼산업 발전 전략
전창곤
,
최세균
한국농촌경제연구원 기본연구보고서
2013
.12
진세노사이드 Rd의 AMPK 및 PPAR 감마의 신호전달경로를 통한 항비만효과
김명선
,
이명수
,
김순희
외 6명
KSBB Journal
2007
.10
Evaluating the correlation between the selective in vitro cellular uptake and the pharmacokinetics of nanoparticles in tumor-bearing mice
장혜윤
,
권익찬
,
김광명
한국고분자학회 학술대회 연구논문 초록집
2014
.10
SD rat의 경구투여를 통한 파라벤의 pharmacokinetics
정평화
,
하성훈
,
안효진
외 6명
환경독성보건학회 심포지엄 및 학술대회
2013
.10
정약용의 전제개혁론의 역사적 매락
이정철
한국사학보
2012
.05
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-520-002777946