지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.9
- 수록면
- 233 - 238 (6page)
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Aspirin is still the mainstay of antiplatelet therapy in the cardiovascular and cerebrovascular disease. However, some patients are not responsive to the antithrombotic action of aspirin. The aim of this study was to assess the prevalence and clinical characteristics of aspirin resistance in patients with cerebral infarction. We tested platelet function in 557 patients who had been treated with aspirin in J general hospital. Platelet function was tested using the multiple electrode platelet aggregometry (MEA). Platelet reactivity was expressed as area under the aggregation curve (AUC, U) and >30 AUC was defined as aspirin resistance. Aspirin resistance was detected in 16.2% patients. There was not any significant differences in age, gender between aspirin resistance and aspirin sensitive patients. WBC was significantly higher in patients with aspirin resistance (P < .05). HDL-cholesterol was significantly higher in patients with aspirin sensitive (P < .05). Aspirin resistance was positive correlation with platelet count (r =.314, P =.003). The prevalence of aspirin resistance in cerebral infarction was 16.2%, and platelet count were related with aspirin resistance.
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REFERENCES
참고문헌 (27)
참고문헌 신청
Abaci A / 2005 / Effect of increasing doses of aspirin on platelet function as measured by PFA-100 in patients with diabetes / Thromb Res 116:465~470
Antithrombotic Trialists' Collaboration / 2002 / Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients / BMJ 324:71~86
Chen WH / 2007 / Aspirin resistance and adverse clinical events in patients with coronary artery disease / Am J Med 120:631~635
Comerota AJ / 2005 / Effect on platelet function of cilostazol, clopidogrel, and aspirin, each alone or in combination / Atheroscler Suppl 6:13~19
Eikelboom JW / 2008 / Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) Investigators. Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid: determinants and effect on cardiovascular risk / Circulation 118:1705~1712
Antithrombotic Trialists' Collaboration / 2002 / Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients / BMJ 324:71~86
Chen WH / 2007 / Aspirin resistance and adverse clinical events in patients with coronary artery disease / Am J Med 120:631~635
Comerota AJ / 2005 / Effect on platelet function of cilostazol, clopidogrel, and aspirin, each alone or in combination / Atheroscler Suppl 6:13~19
Eikelboom JW / 2008 / Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) Investigators. Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid: determinants and effect on cardiovascular risk / Circulation 118:1705~1712
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UCI(KEPA) : I410-ECN-0101-2014-500-002673941