지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.4
- 수록면
- 35 - 44 (10page)
이용수
초록· 키워드
오류제보하기
It is well known that trauma during childhood significantly increases risk for posttraumatic stress disorder(PTSD), other mood and anxiety disorder in adulthood. Childhood trauma is known as altered regulations of the HPA axis in adulthood. Considering the importance of the HPA system in the etiology of PTSD, the effect of childhhood trauma on adult with PTSD and other psychiatric disorders may be mediated by dysregulation of the HPA axis. Recently, it has been recognized that for the development of PTSD, complex interplay between genetic predisposition and environmental factors plays crucial roles. FKBP5, which is a HSP90-associated co-chaperone, regulates sensitivity of glucocorticoid receptor. Multiple studies replicated the findings that interaction of FKBP5 genetic variants and childhood trauma significantly increased the risk of adult PTSD, suicide attempt and aggressive behaviour. Recent studies suggest that in specific risk allele of FKBP5 single nucleotide polymorphism(SNP), 3D conformational change of intron increases the expression of FKBP5 in response to stress. In addition, the model which explains the difference of epigenetic modulation of FKBP5 between risk allele and protective allele has been proposed. The findings that in FKBP5 SNP risk allele, relative irreversibility of cytosine demethylation by environmental factor occurs only in developmentally vulnerable period, may shed light on molecular underpinnings of long lasting effect of childhood trauma.
목차
서론
외상후스트레스장애와 생물학적 취약성
스트레스와 HPA Axis
Glucocorticoid 신호전달에서 FKBP5의 역할
아동기외상과 FKBP5 유전형의 상호작용과 성인 PTSD의 위험성
FKBP5의 후생유전적 조절 기전
결론
참고문헌
참고문헌 (66)
참고문헌 신청
1. [학술지(정기간행물)] - Kessler RC / 2005 / Lifetime prevalence and age-of-onset distrubution of DSM-IV disorders in the National Comorbidity Survey Replication / Arch Gen Psychiatry 62 : 593 ~ 602
2. [학술지(정기간행물)] - de Vries GJ / 2009 / The lifetime prevalence of traumatic events and posttraumatic stress disorder in the Netherlands / J Trauma Stress 22 : 259 ~ 267
3. [학술지(정기간행물)] - Chapman DP / 2004 / Adverse childhood experiences and the risk of depressive disorders in adulthood / J Affect Disord 82 : 217 ~ 225
4. [학술지(정기간행물)] - Holmes W / 1998 / Sexual abuse of boys: definition, prevalence, correlates, sequelae, and management / JAMA 280 : 1855 ~ 1862
5. [학술지(정기간행물)] - MaMillan H / 1997 / Prevalence of child physical and sexual abuse in the community. Results from the Ontario Health Supplement / JAMA 278 : 131 ~ 135
2. [학술지(정기간행물)] - de Vries GJ / 2009 / The lifetime prevalence of traumatic events and posttraumatic stress disorder in the Netherlands / J Trauma Stress 22 : 259 ~ 267
3. [학술지(정기간행물)] - Chapman DP / 2004 / Adverse childhood experiences and the risk of depressive disorders in adulthood / J Affect Disord 82 : 217 ~ 225
4. [학술지(정기간행물)] - Holmes W / 1998 / Sexual abuse of boys: definition, prevalence, correlates, sequelae, and management / JAMA 280 : 1855 ~ 1862
5. [학술지(정기간행물)] - MaMillan H / 1997 / Prevalence of child physical and sexual abuse in the community. Results from the Ontario Health Supplement / JAMA 278 : 131 ~ 135
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UCI(KEPA) : I410-ECN-0101-2015-510-001452099