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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.4
- 수록면
- 1,563 - 1,570 (8page)
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In this study, we investigated the effects of exercise and DL-α-lipoic acid on caspase-3, Mn-superoxide dismutase(SOD), and CU,Zn-SOD levels in hippocampus of aged rats induced by D-galactose. Forty male Sprague-Dawley(SD) rats were divided into four goups: aging/control group(ACG, n=10), aging/exercise group(AEG, n=10), aging/lipoic acid group(ALG, n=10), aging/exercise/lipoic acid group(AELG, n=10). After dividing groups, all groups were injected D-galactose(50㎎/㎏/day) during 8weeks. ALG and AELG were injected DL-α-lipoic acid(100㎎/㎏/day) and ACG was injected vehicle. Rats were subjected to treadmill exercise for 5days a week over 8 weeks, and the speed of the treadmill was gradually increased. For results, significant increases in Mn-SOD protein levels were observed in the hippocampus of AEG, ALG and AELG compared to ACG(p＜.05). CU,Zn-SOD protein levels significantly increased in the AEG and AELG compared to ACG(p＜.05). Caspase-3 protein levels significantly decreased in the AEG, ALG and AELG compared to ACG(p＜.05). Especially, AELG was significantly increased better than others in all protein levels(p＜.05). These results show that exercise combined with DL-α-lipoic acid is more effective to improve Mn-SOD, Cu,Zn-SOD and caspase-3 levels in hippocampus of aged rats induced D-galactose.
목차
Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과
Ⅳ. 논의
Ⅴ. 결론
참고문헌
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Arivazhagan, P. / 2001 / Effect of DL-α- lipoic acid on glutathion metabolic enzymes in aged rats / Experimental Gerontology 37 (1) : 81 ~ 87
2. [학술지(정기간행물)] - Corasaniti, M. T. / 2003 / Neurobiological mediators of neuronal apoptosis in experimental neuroAIDS / Toxicology Letters 139 (2-3) : 199 ~ 206
3. [학술지(정기간행물)] - Cui, X. / 2006 / Chrinic system D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R-α-lipoic acid / Journal of Neuroscience Research 84 : 647 ~ 654
4. [학술지(정기간행물)] - Dixit, S. / 2011 / Protective role of exogenous α-lipoic acid (ALA) on hippocampal antioxidant status and memory function in rat pups exposed to sodium arsenite during the early post-natal period / Toxicology Mechanisms and Methods 21 (3) : 216 ~ 224
5. [학술지(정기간행물)] - Evans, W. J. / 2000 / Vitamin E, Vitamin C and exercise / The American Journal of Clinical Nutrition 72 : 647s ~ 652s
2. [학술지(정기간행물)] - Corasaniti, M. T. / 2003 / Neurobiological mediators of neuronal apoptosis in experimental neuroAIDS / Toxicology Letters 139 (2-3) : 199 ~ 206
3. [학술지(정기간행물)] - Cui, X. / 2006 / Chrinic system D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R-α-lipoic acid / Journal of Neuroscience Research 84 : 647 ~ 654
4. [학술지(정기간행물)] - Dixit, S. / 2011 / Protective role of exogenous α-lipoic acid (ALA) on hippocampal antioxidant status and memory function in rat pups exposed to sodium arsenite during the early post-natal period / Toxicology Mechanisms and Methods 21 (3) : 216 ~ 224
5. [학술지(정기간행물)] - Evans, W. J. / 2000 / Vitamin E, Vitamin C and exercise / The American Journal of Clinical Nutrition 72 : 647s ~ 652s
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UCI(KEPA) : I410-ECN-0101-2015-690-001427611