지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.8
- 수록면
- 263 - 270 (8page)
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초록· 키워드
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This study reports significant improvement of atopic dermatitis condition as a result of experiment using Xanthium strumarium L. extract (XS-E) at the dorsal skin of induced atopic dermatitis Nc/Nga mice. Skin clinical score has decreased (2.75±0.85, *p<0.05), showing visible change of skin condition. IgE (***p<0.001) and IgG1 (2522.00±32.80, ***p<0.001) in plasma also decreased significantly. mRNA (gene expression) level increased (RQ=2.75±0.10, ***p<0.001) within skin tissue of CD4+CD25+Foxp3+ Treg cell that’s activated by XS-E dosage, thereby discovering that there is an effect of suppressing proliferation and viability of Th2 cell, eosinophils, mast cell and inflammatory cell. Upon examining cells permeated with H&E and toluidine blue staining technique, thickness of epidermis and mast cell’s permeation decreased, and the result of examining the distribution of CCR 3+ eosinophils within ALN showed that it’s level fell down to that of wild type (normal group, NC/Nga-WT). By such results, it is suggested that XS-E is highly effective on atopic dermatitis, and it is considered that continued quantitative research and case study of clinical research such as effect of cell number in individual tissues or change of total cell number are necessary.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHOD
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCES
참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Sicherer, S. H. / 1999 / Food hypersensitivity and atopic dermatitis: Pathophysiology, epidemiology, diagnosis, and management / Allergy. Clinical Immunol 104 : 114 ~ 122
2. [학술지(정기간행물)] - Rousset, F. / 1991 / Shifts in interleukin-4and interferon-gamma production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis / Allergy Clin Immunol 87 : 58 ~ 69
3. [학술지(정기간행물)] - Kleij, H. P. / 2004 / Murine model for non-IgE-mediated Asthma / Inflammation 28 : 115 ~ 125
4. [학위논문] - LEE, M. Y / 2002 / Hydroquinone, a metabolite of benzene, enhances interleukin-4 production in CD4+ T cells and increases IgE levels in antigen-primed mice / 박사 / Chunnam National University
5. [학술지(정기간행물)] - Matsumoto, M. / 1999 / IgE hyperproduction through enhanced tyrosine phosphorylation of Janus kinase 3 in NC/Nga mice, a model for human atopic dermatitis / Immunol 162 : 1056 ~ 1063
2. [학술지(정기간행물)] - Rousset, F. / 1991 / Shifts in interleukin-4and interferon-gamma production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis / Allergy Clin Immunol 87 : 58 ~ 69
3. [학술지(정기간행물)] - Kleij, H. P. / 2004 / Murine model for non-IgE-mediated Asthma / Inflammation 28 : 115 ~ 125
4. [학위논문] - LEE, M. Y / 2002 / Hydroquinone, a metabolite of benzene, enhances interleukin-4 production in CD4+ T cells and increases IgE levels in antigen-primed mice / 박사 / Chunnam National University
5. [학술지(정기간행물)] - Matsumoto, M. / 1999 / IgE hyperproduction through enhanced tyrosine phosphorylation of Janus kinase 3 in NC/Nga mice, a model for human atopic dermatitis / Immunol 162 : 1056 ~ 1063
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UCI(KEPA) : I410-ECN-0101-2015-400-002657139