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자료유형
학술저널
저자정보
저널정보
대한지역사회영양학회 Journal of Community Nutrition Journal of Community Nutrition Vol.7 No.3
발행연도
2005.9
수록면
163 - 168 (6page)

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The present investigation was undertaken in vivo to determine whether the functional alterations of hepatic mitochondria induced by ethanol might be prevented by taurine. We examined the effects of supplementation of taurine on hepatic mitochondrial oxidative phosphorylation in the chronic ethanol-administered rates. Isolated hepatic mitochondria from three groups of rats were functionally tested by an analysis of β-hydroxbutyrate-supported respiration and the coupling of this process to ATP synthesis in the presence of ADP. The three groups were control group(CO), ethanol(60g/L) administered group(AL), and ethanol(60g/L) + taurine(5g/L) supplemented group(AT). Ethanol and/or taurine were given in drinking water for 10 weeks. The mitochondria from AL group had lower state 4 respiratory rate, respiratory control(RC) ratio and ADP : O(P/O) ratio those from CO and AT group. It showed that the ethanol administered rats were less coupled and thus less efficient with respect to mitochondrial ATP synthesis than both control rats and ethanol + taurine supplemented rats. It suggests that taurine supplementation might improve the impaired oxidative phosphorylation efficiency in mitochondrial dysfunction that is recognized as a cause of liver diseased in chronic ethanol consumption.

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ABSTRACT

Introduction

Materials and Methods

Results

Discussion

Summary and Conclusion

References

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